eF-site ID 2bfd-A PDB Code 2bfd Chain A click to enlarge Title Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch Classification OXIDOREDUCTASE Compound 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT Source (ODBB_HUMAN) Sequence A:  KPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIIN PSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISF YMTNYGEEGTHVGSAAALDNTDLVFGQAREAGVLMYRDYP LELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLA TQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGF NFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPG YGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMT YRIGSTDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVM EAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHL QTYGEHYPLDHFDK Description Functional site 1) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 2) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE K A 501 source : AC1 3) chain A residue 163 type sequence P description BINDING SITE FOR RESIDUE K A 501 source : AC1 4) chain A residue 166 type sequence T description BINDING SITE FOR RESIDUE K A 501 source : AC1 5) chain A residue 167 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 6) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE MN A 503 source : AC2 7) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE MN A 503 source : AC2 8) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE MN A 503 source : AC2 9) chain A residue 53 type sequence P description BINDING SITE FOR RESIDUE CL A 504 source : AC3 10) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE CL A 504 source : AC3 11) chain A residue 369 type sequence Q description BINDING SITE FOR RESIDUE CL A 504 source : AC3 12) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 13) chain A residue 114 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 14) chain A residue 162 type sequence S description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 15) chain A residue 164 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 16) chain A residue 192 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 17) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 18) chain A residue 194 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 19) chain A residue 195 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 20) chain A residue 198 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 21) chain A residue 220 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 22) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 23) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 24) chain A residue 225 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 25) chain A residue 226 type sequence I description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 26) chain A residue 374 type sequence Q description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 27) chain A residue 73 type sequence I description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 28) chain A residue 76 type sequence E description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 29) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 30) chain A residue 349 type sequence F description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 31) chain A residue 76 type catalytic sequence E description 280 source MCSA : MCSA1 32) chain A residue 162 type catalytic sequence S description 280 source MCSA : MCSA1 33) chain A residue 292 type catalytic sequence S description 280 source MCSA : MCSA1 34) chain A residue 195 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 35) chain A residue 220 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 36) chain A residue 222 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 37) chain A residue 224 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 38) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 39) chain A residue 194 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 40) chain A residue 335 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P50136 source Swiss-Prot : SWS_FT_FI6

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