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eF-site ID
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2be5-M |
PDB Code
|
2be5 |
Chain
|
M |
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click to enlarge
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Title
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Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin |
Classification
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TRANSFERASE |
Compound
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DNA-directed RNA polymerase alpha chain |
Source
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ORGANISM_SCIENTIFIC: Thermus thermophilus; |
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Sequence
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M: |
MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE
NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ
DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL
MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA
SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL
GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT
LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK
LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH
EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML
MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP
LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP
VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT
DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE
PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM
GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED
GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR
PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD
GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE
RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS
FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV
VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA
NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM
NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ
AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE
EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM
VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL
EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS
VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR
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Description
|
|
Functional site
|
|
1)
|
chain |
M |
residue |
685 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE MG N 9006
|
source |
: AC9
|
|
2)
|
chain |
M |
residue |
879 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE MG N 9006
|
source |
: AC9
|
|
3)
|
chain |
M |
residue |
557 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE TGT N 9002
|
source |
: BC1
|
|
4)
|
chain |
M |
residue |
878 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE TGT N 9002
|
source |
: BC1
|
|
5)
|
chain |
M |
residue |
879 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE TGT N 9002
|
source |
: BC1
|
|
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