eF-site ID 2be5-KLMNOP PDB Code 2be5 Chain K, L, M, N, O, P click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence K:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ L:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ M:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR N:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA O:  AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLE PEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVP EDRLQKEMERIYPGE P:  KISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAI KKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDP KTVEEIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLR LVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRF KFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSR TARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQE PVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEE LEKALSKLSEREAMVLKLRKGLIDGEEVGAFFGVTRERIR QIENKALRKLKYHESRTRKLRDFLD Description Functional site 1) chain N residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN N 9059 source : AC6 2) chain N residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN N 9059 source : AC6 3) chain N residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN N 9059 source : AC6 4) chain N residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN N 9059 source : AC6 5) chain N residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN N 9113 source : AC7 6) chain N residue 1189 type sequence R description BINDING SITE FOR RESIDUE ZN N 9113 source : AC7 7) chain N residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN N 9113 source : AC7 8) chain N residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN N 9113 source : AC7 9) chain N residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN N 9113 source : AC7 10) chain N residue 739 type sequence D description BINDING SITE FOR RESIDUE MG N 9005 source : AC8 11) chain N residue 741 type sequence D description BINDING SITE FOR RESIDUE MG N 9005 source : AC8 12) chain N residue 743 type sequence D description BINDING SITE FOR RESIDUE MG N 9005 source : AC8 13) chain M residue 685 type sequence E description BINDING SITE FOR RESIDUE MG N 9006 source : AC9 14) chain M residue 879 type sequence R description BINDING SITE FOR RESIDUE MG N 9006 source : AC9 15) chain N residue 739 type sequence D description BINDING SITE FOR RESIDUE MG N 9006 source : AC9 16) chain M residue 557 type sequence R description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 17) chain M residue 878 type sequence S description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 18) chain M residue 879 type sequence R description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 19) chain N residue 737 type sequence N description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 20) chain N residue 783 type sequence R description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 21) chain N residue 1029 type sequence R description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 22) chain N residue 1031 type sequence N description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 23) chain N residue 1034 type sequence Q description BINDING SITE FOR RESIDUE TGT N 9002 source : BC1 24) chain N residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain N residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 26) chain N residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 27) chain N residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 28) chain N residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 29) chain N residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 30) chain N residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 31) chain N residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 32) chain N residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 33) chain N residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 34) chain N residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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