eF-site ID 2be2-AB PDB Code 2be2 Chain A, B click to enlarge Title Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239 Classification TRANSFERASE Compound REVERSE TRANSCRIPTASE P66 SUBUNIT Source null (POL_HV1B1) Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF YVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQ IIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV B:  PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKR TQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDED FRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSS MTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIE ELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQP IVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLL RGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSK DLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTN DVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWT EYWQATWIPEWEFVNTPPLVKLWYQL Description Functional site 1) chain A residue 479 type SITE sequence L description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 499 type SITE sequence S description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 550 type SITE sequence K description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization source Swiss-Prot : SWS_FT_FI4 5) chain A residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization source Swiss-Prot : SWS_FT_FI4 6) chain A residue 441 type SITE sequence Y description Cleavage; by viral protease; partial source Swiss-Prot : SWS_FT_FI5 7) chain B residue 111 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 8) chain B residue 186 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 9) chain B residue 187 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 10) chain B residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization source Swiss-Prot : SWS_FT_FI3 11) chain B residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization source Swiss-Prot : SWS_FT_FI3

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