eF-site ID 2be2-A
PDB Code 2be2
Chain A

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Title Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
Classification TRANSFERASE
Compound REVERSE TRANSCRIPTASE P66 SUBUNIT
Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1)
Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF
YVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQ
IIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV
Description


Functional site
1) chain A
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization
source Swiss-Prot : SWS_FT_FI4
2) chain A
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization
source Swiss-Prot : SWS_FT_FI4
3) chain A
residue 441
type SITE
sequence Y
description Cleavage; by viral protease; partial
source Swiss-Prot : SWS_FT_FI5
4) chain A
residue 479
type SITE
sequence L
description Cleavage; by viral protease => ECO:0000269|PubMed:2476069
source Swiss-Prot : SWS_FT_FI2
5) chain A
residue 499
type SITE
sequence S
description Cleavage; by viral protease => ECO:0000269|PubMed:2476069
source Swiss-Prot : SWS_FT_FI2
6) chain A
residue 550
type SITE
sequence K
description Cleavage; by viral protease => ECO:0000269|PubMed:2476069
source Swiss-Prot : SWS_FT_FI2

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