eF-site ID 2bd4-AP PDB Code 2bd4 Chain A, P click to enlarge Title Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5.0 Classification HYDROLASE Compound beta-casomorphin-7 Source ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa; Sequence A:  VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWV MTAAHCVDRELTFRVVVGEHNLNQNNGTEQYVGVQKIVVH PYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTI LANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSS SSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQY AVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN P:  I Description Functional site 1) chain A residue 70 type sequence E description BINDING SITE FOR RESIDUE CA A 260 source : AC1 2) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 260 source : AC1 3) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA A 260 source : AC1 4) chain A residue 77 type sequence N description BINDING SITE FOR RESIDUE CA A 260 source : AC1 5) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A 260 source : AC1 6) chain A residue 127 type sequence G description BINDING SITE FOR RESIDUE SO4 A 270 source : AC2 7) chain A residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 A 270 source : AC2 8) chain A residue 230 type sequence R description BINDING SITE FOR RESIDUE SO4 A 270 source : AC2 9) chain A residue 232 type sequence S description BINDING SITE FOR RESIDUE SO4 A 270 source : AC2 10) chain A residue 233 type sequence A description BINDING SITE FOR RESIDUE SO4 A 270 source : AC2 11) chain A residue 41 type sequence T description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 12) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 13) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 14) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 15) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 16) chain P residue 7 type sequence I description BINDING SITE FOR RESIDUE LYS P 1001 source : AC3 17) chain A residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:4578945, ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 53-58 type prosite sequence MTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC source prosite : PS00134 21) chain A residue 189-200 type prosite sequence SGCQGDSGGPLH description TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH source prosite : PS00135 22) chain A residue 72 type BINDING sequence N description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 23) chain A residue 70 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 24) chain A residue 80 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 25) chain A residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3

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