eF-site ID 2b9s-ABCDE
PDB Code 2b9s
Chain A, B, C, D, E

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Title Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex
Classification ISOMERASE/DNA
Compound 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'
Source (2B9S)
Sequence A:  DLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIP
IFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVFRRNFF
ESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRT
KEEKKAIKEKQDAEAEPYRYCVWDGRREQVANFRVEPPGL
FRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHK
WAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSD
MVKFEKARKLKDKVDDIRASYMEDFKSNDLHVAQRAVAMY
FIDRLALRVGNEKGEDEADTVGCCSLRVEHIQLMPDNIVR
FDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFD
QLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKP
WSTADKLAYFNKANTEVAILCNHQKS
B:  KAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKK
FPWAMNAENFDF
C:  AAAAAGACTT
D:  AGAAAAATTTTT
E:  AAAAATTTTTCTAAGTCTTTTT
Description


Functional site

1) chain A
residue 314
type
sequence R
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1

2) chain A
residue 410
type
sequence R
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1

3) chain A
residue 453
type
sequence H
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1

4) chain B
residue 222
type
sequence Y
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1

5) chain C
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1

6) chain D
residue 11
type
sequence A
description BINDING SITE FOR RESIDUE VO4 B 301
source : AC1


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