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eF-site ID
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2b8k-B |
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PDB Code
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2b8k |
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Chain
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B |
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click to enlarge
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Title
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12-subunit RNA Polymerase II |
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Classification
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TRANSFERASE |
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Compound
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DNA-directed RNA polymerase II largest subunit |
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Source
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ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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B: |
DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTL
QDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEAR
LRNLTYSSGLFVDVKKKVFIGRLPIMLRSKNCYLSEATES
DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK
KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR
TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND
WQMLEMLKPCVEDGFVIQDRETALDFIGKEKRIQYAKDIL
QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQD
DRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV
EEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSR
AGVSQVLNRYTYSSTLSHLRRTNTPIAKPRQLHNTHWGLV
CPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWG
MEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRT
LRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVED
DESLGHKELKVRKGHIAKLMATEYQDEYTWSSLLNEGLVE
YIDAEEEESILIAMQPEDLEPAEADVDPAKRIRVSHHATT
FTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQA
MGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFREL
PAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFR
SYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDG
LIAPGVRVSGEDVIIGKTTPISSKRDASTPLRSTENGIVD
QVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTI
GITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECL
LSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFE
VMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGP
MQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKER
LMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKID
IYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF
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Description
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(1) |
DNA-directed RNA polymerase II largest subunit (E.C.2.7.7.6), DNA-directed RNA polymerase II 140 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 45 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 32 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 19 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II subunit 9 (E.C.2.7.7.6), DNA-directed RNA polymerases I/II/III subunit 10 (E.C.2.7.7.6), DNA-directed RNA polymerase II 13.6 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 7.7 kDa polypeptide (E.C.2.7.7.6)
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Functional site
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1)
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chain |
B |
| residue |
1163 |
| type |
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| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN B 1225
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| source |
: AC3
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2)
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chain |
B |
| residue |
1166 |
| type |
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| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN B 1225
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| source |
: AC3
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3)
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chain |
B |
| residue |
1170 |
| type |
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| sequence |
T
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| description |
BINDING SITE FOR RESIDUE ZN B 1225
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| source |
: AC3
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4)
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chain |
B |
| residue |
1182 |
| type |
|
| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN B 1225
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| source |
: AC3
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|
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5)
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chain |
B |
| residue |
1185 |
| type |
|
| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN B 1225
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| source |
: AC3
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|
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6)
|
chain |
B |
| residue |
977-989 |
| type |
prosite |
| sequence |
GDKFASRHGQKGT
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| description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
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| source |
prosite : PS01166
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7)
|
chain |
B |
| residue |
837 |
| type |
catalytic |
| sequence |
D
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| description |
788
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| source |
MCSA : MCSA1
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8)
|
chain |
B |
| residue |
1185 |
| type |
BINDING |
| sequence |
C
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
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