|
eF-site ID
|
2b8k-A |
PDB Code
|
2b8k |
Chain
|
A |
|
click to enlarge
|
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Title
|
12-subunit RNA Polymerase II |
Classification
|
TRANSFERASE |
Compound
|
DNA-directed RNA polymerase II largest subunit |
Source
|
ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
|
A: |
VGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETM
DETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHF
GHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNEL
MRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQL
VSRGGCGNTQPTIRKDGLKLVGSWKDEPELRVLSTEEILN
IFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPS
ISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAI
EEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARL
KGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKS
IAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDS
GDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPS
LHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNL
HVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLC
GIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPK
PLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIID
GQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNI
QKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKK
VLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKA
GRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQS
VEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLT
PQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIM
VHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGS
DAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLL
DEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQ
TFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQN
AQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNI
EAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLKKVTSGVP
RLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIE
HTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLQQS
PWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWS
EDNDEKLIIRCRVVAEEDHMLKKIENTMLENITLRGVENI
ERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTV
PGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASD
GSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMR
CSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTG
AFDVMIDEESLVKYMP
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Description
|
(1) |
DNA-directed RNA polymerase II largest subunit (E.C.2.7.7.6), DNA-directed RNA polymerase II 140 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 45 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 32 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II 19 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerase II subunit 9 (E.C.2.7.7.6), DNA-directed RNA polymerases I/II/III subunit 10 (E.C.2.7.7.6), DNA-directed RNA polymerase II 13.6 kDa polypeptide (E.C.2.7.7.6), DNA-directed RNA polymerases I, II, and III 7.7 kDa polypeptide (E.C.2.7.7.6)
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
108 |
type |
|
sequence |
M
|
description |
BINDING SITE FOR RESIDUE ZN A 1734
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
110 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1734
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
148 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1734
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
167 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1734
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
67 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1735
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
68 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE ZN A 1735
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
70 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1735
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
77 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 1735
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
80 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 1735
|
source |
: AC2
|
|
10)
|
chain |
A |
residue |
483 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
11)
|
chain |
A |
residue |
485 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
12)
|
chain |
A |
residue |
483 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
13)
|
chain |
A |
residue |
485 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
14)
|
chain |
A |
residue |
107 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
15)
|
chain |
A |
residue |
110 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
16)
|
chain |
A |
residue |
148 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
17)
|
chain |
A |
residue |
167 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
18)
|
chain |
A |
residue |
481 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|