eF-site ID 2b4j-ABCD PDB Code 2b4j Chain A, B, C, D click to enlarge Title Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 Classification viral protein, recombination Compound Integrase (IN) Source Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) (PSIP1_HUMAN) Sequence A:  CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQ ETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGI KQEFVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNK KSAGERIVDIIATDI B:  SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQE TAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIK QEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAV QMAVFIHNKKRSAGERIVDIIATDI C:  GSSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQ VTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFK NM D:  GSSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQ VTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFK NM Description Functional site 1) chain A residue 66 type sequence T description BINDING SITE FOR RESIDUE PO4 A 301 source : AC1 2) chain A residue 67 type sequence H description BINDING SITE FOR RESIDUE PO4 A 301 source : AC1 3) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE PO4 A 301 source : AC1 4) chain D residue 392 type sequence K description BINDING SITE FOR RESIDUE PO4 A 301 source : AC1 5) chain B residue 66 type sequence T description BINDING SITE FOR RESIDUE PO4 B 302 source : AC2 6) chain B residue 67 type sequence H description BINDING SITE FOR RESIDUE PO4 B 302 source : AC2 7) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE PO4 B 302 source : AC2 8) chain C residue 392 type sequence K description BINDING SITE FOR RESIDUE PO4 B 302 source : AC2 9) chain C residue 352 type sequence L description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 10) chain C residue 353 type sequence Q description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 11) chain C residue 356 type sequence H description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 12) chain C residue 393 type sequence H description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 13) chain C residue 395 type sequence E description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 14) chain C residue 396 type sequence M description BINDING SITE FOR RESIDUE GOL C 443 source : AC3 15) chain D residue 352 type sequence L description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 16) chain D residue 353 type sequence Q description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 17) chain D residue 356 type sequence H description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 18) chain D residue 393 type sequence H description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 19) chain D residue 395 type sequence E description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 20) chain D residue 396 type sequence M description BINDING SITE FOR RESIDUE GOL D 443 source : AC4 21) chain B residue 71 type sequence K description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 22) chain B residue 71 type sequence K description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 23) chain B residue 171 type sequence H description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 24) chain B residue 172 type sequence L description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 25) chain A residue 71 type sequence K description BINDING SITE FOR RESIDUE GOL A 404 source : AC6 26) chain A residue 171 type sequence H description BINDING SITE FOR RESIDUE GOL A 404 source : AC6 27) chain A residue 172 type sequence L description BINDING SITE FOR RESIDUE GOL A 404 source : AC6 28) chain B residue 57 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 58 type MOD_RES sequence P description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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