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eF-site ID
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2ayo-A |
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PDB Code
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2ayo |
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Chain
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A |
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click to enlarge
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Title
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Structure of USP14 bound to ubquitin aldehyde |
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Classification
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HYDROLASE |
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Compound
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Ubiquitin carboxyl-terminal hydrolase 14 |
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Source
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Homo sapiens (Human) (UBIQ_HUMAN) |
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Sequence
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A: |
ASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYA
GALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQ
FLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEA
IEDDTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKE
NQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNAL
YIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFP
LMLDMYELCTPELQEKMVSFRSKFKDLEDEVKYEPFSFAD
DIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWI
KFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPR
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Description
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Functional site
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1)
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chain |
A |
| residue |
302 |
| type |
CROSSLNK |
| sequence |
P
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
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| source |
Swiss-Prot : SWS_FT_FI6
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2)
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chain |
A |
| residue |
432 |
| type |
CROSSLNK |
| sequence |
S
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
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| source |
Swiss-Prot : SWS_FT_FI6
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3)
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chain |
A |
| residue |
105-120 |
| type |
prosite |
| sequence |
GLTNLGNTCYMNATVQ
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| description |
USP_1 Ubiquitin specific protease (USP) domain signature 1. GLtnlGNtCYMNAtVQ
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| source |
prosite : PS00972
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4)
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chain |
A |
| residue |
417-435 |
| type |
prosite |
| sequence |
YDLQAVLTHQGRSSSSGHY
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| description |
USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLqAVltHqGrssss.GHY
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| source |
prosite : PS00973
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5)
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chain |
A |
| residue |
449 |
| type |
CROSSLNK |
| sequence |
F
|
| description |
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
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| source |
Swiss-Prot : SWS_FT_FI7
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