|
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eF-site ID
|
2aw5-C |
|
PDB Code
|
2aw5 |
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Chain
|
C |
|
click to enlarge
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Title
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Crystal structure of a human malic enzyme |
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Classification
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OXIDOREDUCTASE |
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Compound
|
NADP-dependent malic enzyme |
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Source
|
Homo sapiens (Human) (MAOX_HUMAN) |
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Sequence
|
C: |
GYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQ
VLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDI
EKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIA
SVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKL
ALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQR
RVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFR
LLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSD
QTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLV
DSKGLIVKGQEKEKFAHEHEEMKNLEAIVQEIKPTALIGV
AAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQ
CYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFP
GVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRL
YPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAF
VRSQMYSTDYDQI
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Description
|
|
Functional site
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|
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1)
|
chain |
C |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
Proton donor => ECO:0000250|UniProtKB:P23368
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
C |
| residue |
269 |
| type |
SITE |
| sequence |
D
|
| description |
Important for activity => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
C |
| residue |
336 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P06801
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
C |
| residue |
173 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
Proton acceptor => ECO:0000250|UniProtKB:P23368
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
C |
| residue |
269 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
C |
| residue |
301 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
C |
| residue |
408 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
8)
|
chain |
C |
| residue |
155 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
C |
| residue |
245 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P23368
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
C |
| residue |
246 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P23368
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|