eF-site ID 2aw5-A
PDB Code 2aw5
Chain A

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Title Crystal structure of a human malic enzyme
Classification OXIDOREDUCTASE
Compound NADP-dependent malic enzyme
Source Homo sapiens (Human) (MAOX_HUMAN)
Sequence A:  GYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQ
VLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSIE
KFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIAS
VLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLA
LYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRR
VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRL
LNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQ
TILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVD
SKGLIVKGQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVA
AIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPG
VALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLY
PPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV
RSQMYSTDYDQ
Description


Functional site

1) chain A
residue 266-282
type prosite
sequence FNDDIQGTASVAVAGLL
description MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGLL
source prosite : PS00331

2) chain A
residue 102
type ACT_SITE
sequence Y
description Proton donor => ECO:0000250|UniProtKB:P23368
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 173
type ACT_SITE
sequence K
description Proton acceptor => ECO:0000250|UniProtKB:P23368
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 155
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 269
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 301
type BINDING
sequence G
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 408
type BINDING
sequence N
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

8) chain A
residue 245
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P23368
source Swiss-Prot : SWS_FT_FI4

9) chain A
residue 246
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P23368
source Swiss-Prot : SWS_FT_FI4

10) chain A
residue 269
type SITE
sequence D
description Important for activity => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

11) chain A
residue 336
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P06801
source Swiss-Prot : SWS_FT_FI6


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