eF-site ID 2aw5-A PDB Code 2aw5 Chain A click to enlarge Title Crystal structure of a human malic enzyme Classification OXIDOREDUCTASE Compound NADP-dependent malic enzyme Source Homo sapiens (Human) (MAOX_HUMAN) Sequence A:  GYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQ VLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSIE KFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIAS VLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLA LYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRR VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRL LNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQ TILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVD SKGLIVKGQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVA AIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPG VALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLY PPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV RSQMYSTDYDQ Description Functional site 1) chain A residue 266-282 type prosite sequence FNDDIQGTASVAVAGLL description MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGLL source prosite : PS00331 2) chain A residue 102 type ACT_SITE sequence Y description Proton donor => ECO:0000250|UniProtKB:P23368 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 173 type ACT_SITE sequence K description Proton acceptor => ECO:0000250|UniProtKB:P23368 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 155 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 269 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 301 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 7) chain A residue 408 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 245 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P23368 source Swiss-Prot : SWS_FT_FI4 9) chain A residue 246 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P23368 source Swiss-Prot : SWS_FT_FI4 10) chain A residue 269 type SITE sequence D description Important for activity => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 336 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P06801 source Swiss-Prot : SWS_FT_FI6

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