eF-site ID 2ast-ABCD PDB Code 2ast Chain A, B, C, D click to enlarge Title Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide Classification LIGASE/LIGASE INHIBITOR Compound S-phase kinase-associated protein 1A Source Homo sapiens (Human) (CDN1B_HUMAN) Sequence A:  ASIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDPVPL PNVNAAILKKVIQWCTHHKDDPPTDDIPVWDQEFLKVDQG TLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKT FNIKNDFTEEEEAQVRKENQWC B:  VSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDE SLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPL AEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLE GLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSS CSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYR KNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQL NYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDG TLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKC RLTLQ C:  QIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWR NLGVQQSQGWVHYMIHEPEPHILLFRRPL D:  AGSVEQXPKK Description Functional site 1) chain B residue 2169 type sequence F description BINDING SITE FOR RESIDUE BEN C 1001 source : AC1 2) chain B residue 2192 type sequence V description BINDING SITE FOR RESIDUE BEN C 1001 source : AC1 3) chain C residue 3058 type sequence M description BINDING SITE FOR RESIDUE BEN C 1001 source : AC1 4) chain C residue 3070 type sequence R description BINDING SITE FOR RESIDUE BEN C 1001 source : AC1 5) chain B residue 2227 type sequence A description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 6) chain B residue 2230 type sequence S description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 7) chain B residue 2254 type sequence S description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 8) chain C residue 3021 type sequence H description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 9) chain C residue 3060 type sequence H description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 10) chain C residue 3063 type sequence E description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 11) chain C residue 3066 type sequence I description BINDING SITE FOR RESIDUE BEN B 1002 source : AC2 12) chain B residue 2294 type sequence R description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 13) chain B residue 2346 type sequence Y description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 14) chain B residue 2347 type sequence D description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 15) chain C residue 3008 type sequence Y description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 16) chain C residue 3010 type sequence D description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 17) chain C residue 3011 type sequence K description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 18) chain C residue 3020 type sequence R description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 19) chain C residue 3044 type sequence R description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 20) chain C residue 3049 type sequence Q description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 21) chain C residue 3050 type sequence Q description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 22) chain C residue 3051 type sequence S description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 23) chain C residue 3052 type sequence Q description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 24) chain C residue 3054 type sequence W description BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B source : AC3 25) chain C residue 3008-3026 type prosite sequence YSDKYDDEEFEYRHVMLPK description CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK source prosite : PS00944 26) chain C residue 3060-3070 type prosite sequence HEPEPHILLFR description CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR source prosite : PS00945 27) chain D residue 4187 type MOD_RES sequence X description Phosphothreonine; by PKB/AKT1, CDK1 and CDK2 => ECO:0000269|PubMed:10323868, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:23478441 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 1143 type CROSSLNK sequence N description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 source Swiss-Prot : SWS_FT_FI2

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