eF-site ID 2aqv-B PDB Code 2aqv Chain B click to enlarge Title Crystal Structure of E. coli Isoaspartyl Dipeptidase mutant Y137F Classification HYDROLASE Compound Isoaspartyl dipeptidase Source Escherichia coli (strain K12) (IADA_ECOLI) Sequence B:  MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVAS NIPSDIVPNCTVVDLSGQILCPGFIDQHVHLIGGGGEAGP TTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKT RALNEEGISAWMLTGAFHVPSRTITGSVEKDVAIIDRVIG VXCAISDHRSAAPDVYHLANMAAESRVGGLLGGKPGVTVF HMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQ ALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARV TLSSDGNGSVAGFETLLETVQVLVKDYDFSISDALRPLTS SVAGFLNLTGKGEILPGNDADLLVMTPELRIEQVYARGKL MVKDGKACVKGTFET Description Functional site 1) chain B residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN B 803 source : AC3 2) chain B residue 70 type sequence H description BINDING SITE FOR RESIDUE ZN B 803 source : AC3 3) chain B residue 162 type sequence X description BINDING SITE FOR RESIDUE ZN B 803 source : AC3 4) chain B residue 285 type sequence D description BINDING SITE FOR RESIDUE ZN B 803 source : AC3 5) chain B residue 162 type sequence X description BINDING SITE FOR RESIDUE ZN B 804 source : AC4 6) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN B 804 source : AC4 7) chain B residue 230 type sequence H description BINDING SITE FOR RESIDUE ZN B 804 source : AC4 8) chain B residue 68 type catalytic sequence H description 172 source MCSA : MCSA2 9) chain B residue 70 type catalytic sequence H description 172 source MCSA : MCSA2 10) chain B residue 162 type catalytic sequence X description 172 source MCSA : MCSA2 11) chain B residue 201 type catalytic sequence H description 172 source MCSA : MCSA2 12) chain B residue 230 type catalytic sequence H description 172 source MCSA : MCSA2 13) chain B residue 285 type catalytic sequence D description 172 source MCSA : MCSA2 14) chain B residue 285 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:12946361 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 285 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 68 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 70 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 230 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 75 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 21) chain B residue 289 type BINDING sequence S description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 106 type BINDING sequence T description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 137 type BINDING sequence F description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 233 type BINDING sequence R description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 162 type BINDING sequence X description via carbamate group => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI5 27) chain B residue 162 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI6

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