eF-site ID 2aqv-A PDB Code 2aqv Chain A click to enlarge Title Crystal Structure of E. coli Isoaspartyl Dipeptidase mutant Y137F Classification HYDROLASE Compound Isoaspartyl dipeptidase Source Escherichia coli (strain K12) (IADA_ECOLI) Sequence A:  MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVAS NIPSDIVPNCTVVDLSGQILCPGFIDQHVHLIGGGGEAGP TTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKT RALNEEGISAWMLTGAFHVPSRTITGSVEKDVAIIDRVIG VXCAISDHRSAAPDVYHLANMAAESRVGGLLGGKPGVTVF HMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQ ALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARV TLSSDGNGGVAGFETLLETVQVLVKDYDFSISDALRPLTS SVAGFLNLTGKGEILPGNDADLLVMTPELRIEQVYARGKL MVKDGKACVKGTFET Description Functional site 1) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN A 801 source : AC1 2) chain A residue 70 type sequence H description BINDING SITE FOR RESIDUE ZN A 801 source : AC1 3) chain A residue 162 type sequence X description BINDING SITE FOR RESIDUE ZN A 801 source : AC1 4) chain A residue 285 type sequence D description BINDING SITE FOR RESIDUE ZN A 801 source : AC1 5) chain A residue 162 type sequence X description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 6) chain A residue 201 type sequence H description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 7) chain A residue 230 type sequence H description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 8) chain A residue 68 type catalytic sequence H description 172 source MCSA : MCSA1 9) chain A residue 70 type catalytic sequence H description 172 source MCSA : MCSA1 10) chain A residue 162 type catalytic sequence X description 172 source MCSA : MCSA1 11) chain A residue 201 type catalytic sequence H description 172 source MCSA : MCSA1 12) chain A residue 230 type catalytic sequence H description 172 source MCSA : MCSA1 13) chain A residue 285 type catalytic sequence D description 172 source MCSA : MCSA1 14) chain A residue 285 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:12946361 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 68 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 70 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 201 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 230 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 285 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 75 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 21) chain A residue 106 type BINDING sequence T description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 137 type BINDING sequence F description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 233 type BINDING sequence R description BINDING => ECO:0000305|PubMed:12718528, ECO:0000305|PubMed:12946361, ECO:0000305|PubMed:15882050 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 162 type BINDING sequence X description via carbamate group => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI5 26) chain A residue 162 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:12718528, ECO:0000269|PubMed:12946361, ECO:0000269|PubMed:15882050, ECO:0000269|PubMed:16289685 source Swiss-Prot : SWS_FT_FI6

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