eF-site ID 2aqb-D PDB Code 2aqb Chain D click to enlarge Title Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli Classification TRANSFERASE Compound 3-oxoacyl-[acyl-carrier-protein] synthase I Source Escherichia coli (strain K12) (FABB_ECOLI) Sequence D:  KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKD SGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSMEQ AIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISS ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEF DAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVE ELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCM KMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKS PAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINI EELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM RKL Description Functional site 1) chain D residue 163 type sequence C description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 2) chain D residue 229 type sequence F description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 3) chain D residue 270 type sequence V description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 4) chain D residue 271 type sequence A description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 5) chain D residue 272 type sequence P description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 6) chain D residue 298 type sequence H description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 7) chain D residue 300 type sequence T description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 8) chain D residue 333 type sequence H description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 9) chain D residue 390 type sequence F description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 10) chain D residue 391 type sequence G description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 11) chain D residue 392 type sequence F description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 12) chain D residue 394 type sequence G description BINDING SITE FOR RESIDUE TL6 D 602 source : AC3 13) chain D residue 163 type catalytic sequence C description 292 source MCSA : MCSA4 14) chain D residue 298 type catalytic sequence H description 292 source MCSA : MCSA4 15) chain D residue 328 type catalytic sequence K description 292 source MCSA : MCSA4 16) chain D residue 333 type catalytic sequence H description 292 source MCSA : MCSA4 17) chain D residue 390 type catalytic sequence F description 292 source MCSA : MCSA4 18) chain D residue 392 type catalytic sequence F description 292 source MCSA : MCSA4 19) chain D residue 163 type ACT_SITE sequence C description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:10571059 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 298 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 21) chain D residue 333 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2

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