|
|
eF-site ID
|
2aqb-C |
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PDB Code
|
2aqb |
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Chain
|
C |
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click to enlarge
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Title
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Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli |
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Classification
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TRANSFERASE |
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Compound
|
3-oxoacyl-[acyl-carrier-protein] synthase I |
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Source
|
null (FABB_ECOLI) |
|
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Sequence
|
C: |
KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKD
SGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSMEQ
AIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR
GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISS
ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEF
DAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVE
ELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCM
KMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKS
PAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINI
EELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM
RKL
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Description
|
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Functional site
|
|
|
1)
|
chain |
C |
| residue |
298 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
C |
| residue |
333 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
C |
| residue |
163 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:10571059
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
C |
| residue |
163 |
| type |
catalytic |
| sequence |
C
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
5)
|
chain |
C |
| residue |
298 |
| type |
catalytic |
| sequence |
H
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
6)
|
chain |
C |
| residue |
328 |
| type |
catalytic |
| sequence |
K
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
7)
|
chain |
C |
| residue |
333 |
| type |
catalytic |
| sequence |
H
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
8)
|
chain |
C |
| residue |
390 |
| type |
catalytic |
| sequence |
F
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
9)
|
chain |
C |
| residue |
392 |
| type |
catalytic |
| sequence |
F
|
| description |
292
|
| source |
MCSA : MCSA3
|
|
|
|