eF-site ID 2aqb-B PDB Code 2aqb Chain B click to enlarge Title Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli Classification TRANSFERASE Compound 3-oxoacyl-[acyl-carrier-protein] synthase I Source null (FABB_ECOLI) Sequence B:  KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKD SGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSMEQ AIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISS ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEF DAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVE ELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCM KMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKS PAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINI EELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM RKL Description Functional site 1) chain B residue 163 type sequence C description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 2) chain B residue 229 type sequence F description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 3) chain B residue 269 type sequence M description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 4) chain B residue 270 type sequence V description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 5) chain B residue 271 type sequence A description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 6) chain B residue 272 type sequence P description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 7) chain B residue 298 type sequence H description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 8) chain B residue 300 type sequence T description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 9) chain B residue 302 type sequence T description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 10) chain B residue 333 type sequence H description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 11) chain B residue 390 type sequence F description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 12) chain B residue 391 type sequence G description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 13) chain B residue 394 type sequence G description BINDING SITE FOR RESIDUE TL6 B 601 source : AC2 14) chain B residue 298 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 333 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 163 type ACT_SITE sequence C description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:10571059 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 163 type catalytic sequence C description 292 source MCSA : MCSA2 18) chain B residue 298 type catalytic sequence H description 292 source MCSA : MCSA2 19) chain B residue 328 type catalytic sequence K description 292 source MCSA : MCSA2 20) chain B residue 333 type catalytic sequence H description 292 source MCSA : MCSA2 21) chain B residue 390 type catalytic sequence F description 292 source MCSA : MCSA2 22) chain B residue 392 type catalytic sequence F description 292 source MCSA : MCSA2

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