eF-site ID 2aqb-A PDB Code 2aqb Chain A click to enlarge Title Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli Classification TRANSFERASE Compound 3-oxoacyl-[acyl-carrier-protein] synthase I Source null (FABB_ECOLI) Sequence A:  MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELK DSGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSME QAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSIS SACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRC MKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDK SPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLV MRKL Description Functional site 1) chain A residue 163 type sequence C description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 2) chain A residue 229 type sequence F description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 3) chain A residue 268 type sequence D description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 4) chain A residue 269 type sequence M description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 5) chain A residue 270 type sequence V description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 6) chain A residue 271 type sequence A description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 7) chain A residue 272 type sequence P description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 8) chain A residue 298 type sequence H description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 9) chain A residue 300 type sequence T description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 10) chain A residue 302 type sequence T description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 11) chain A residue 333 type sequence H description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 12) chain A residue 390 type sequence F description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 13) chain A residue 391 type sequence G description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 14) chain A residue 392 type sequence F description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 15) chain A residue 394 type sequence G description BINDING SITE FOR RESIDUE TL6 A 600 source : AC1 16) chain A residue 154-170 type prosite sequence GVNYSISSACATSAHCI description KS3_1 Ketosynthase family 3 (KS3) active site signature. GVNysISsACATSahCI source prosite : PS00606 17) chain A residue 298 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 333 type ACT_SITE sequence H description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 163 type ACT_SITE sequence C description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:10571059 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 163 type catalytic sequence C description 292 source MCSA : MCSA1 21) chain A residue 298 type catalytic sequence H description 292 source MCSA : MCSA1 22) chain A residue 328 type catalytic sequence K description 292 source MCSA : MCSA1 23) chain A residue 333 type catalytic sequence H description 292 source MCSA : MCSA1 24) chain A residue 390 type catalytic sequence F description 292 source MCSA : MCSA1 25) chain A residue 392 type catalytic sequence F description 292 source MCSA : MCSA1

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