eF-site ID 2aob-C PDB Code 2aob Chain C click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source Homo sapiens (Human) (GRB2_HUMAN) Sequence C:  KPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDF SLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYH RSTSVSRNQQIFLRDI Description Functional site 1) chain C residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 2) chain C residue 62 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 3) chain C residue 64 type sequence K description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 4) chain C residue 65 type sequence I description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 5) chain C residue 66 type sequence P description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 6) chain C residue 69 type sequence K description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 7) chain C residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 8) chain C residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 9) chain C residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 10) chain C residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 11) chain C residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 12) chain C residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 13) chain C residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 14) chain C residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 15) chain C residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 16) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 17) chain C residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 18) chain C residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 19) chain C residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 20) chain C residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 21) chain C residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 22) chain C residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 23) chain C residue 87 type sequence E description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 24) chain C residue 93 type sequence G description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 25) chain C residue 95 type sequence F description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 26) chain C residue 118 type sequence Y description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 27) chain C residue 58 type sequence H description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 28) chain C residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 29) chain C residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links