eF-site ID 2aob-A PDB Code 2aob Chain A click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source Homo sapiens (Human) (GRB2_HUMAN) Sequence A:  KPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDF SLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYH RSTSVSRNQQIFLRDI Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 2) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 4) chain A residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 6) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 7) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 8) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 9) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 10) chain A residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 11) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 12) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 13) chain A residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 14) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 15) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 16) chain A residue 114 type sequence G description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 17) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 18) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 19) chain A residue 87 type sequence E description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 20) chain A residue 93 type sequence G description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 21) chain A residue 95 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 22) chain A residue 118 type sequence Y description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 23) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 24) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 25) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 26) chain A residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 27) chain A residue 62 type sequence F description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 28) chain A residue 64 type sequence K description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 29) chain A residue 65 type sequence I description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 30) chain A residue 66 type sequence P description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 31) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 32) chain A residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

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