eF-site ID 2aob-ABCD PDB Code 2aob Chain A, B, C, D click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source null (GRB2_HUMAN) Sequence A:  KPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDF SLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYH RSTSVSRNQQIFLRDI B:  PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLS VKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRST SVSRNQQIFLRDI C:  KPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDF SLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYH RSTSVSRNQQIFLRDI D:  PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLS VKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRST SVSRNQQIFLRDI Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 2) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 4) chain A residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 6) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 7) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 8) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 9) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 10) chain A residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 11) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 12) chain D residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 1201 source : AC1 13) chain B residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 14) chain B residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 15) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 16) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 17) chain B residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 18) chain B residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 19) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 20) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 21) chain B residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 22) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 23) chain C residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S B 1301 source : AC2 24) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 25) chain A residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 26) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 27) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 28) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 29) chain B residue 122 type sequence V description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 30) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 31) chain B residue 125 type sequence F description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 32) chain B residue 130 type sequence E description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 33) chain D residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 34) chain D residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S A 1401 source : AC3 35) chain A residue 114 type sequence G description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 36) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 37) chain B residue 126 type sequence N description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 38) chain D residue 112 type sequence R description BINDING SITE FOR RESIDUE S1S A 1501 source : AC4 39) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 40) chain A residue 87 type sequence E description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 41) chain A residue 93 type sequence G description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 42) chain A residue 95 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 43) chain A residue 118 type sequence Y description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 44) chain B residue 127 type sequence S description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 45) chain B residue 128 type sequence L description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 46) chain C residue 62 type sequence F description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 47) chain C residue 64 type sequence K description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 48) chain C residue 65 type sequence I description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 49) chain C residue 66 type sequence P description BINDING SITE FOR RESIDUE S1S A 1601 source : AC5 50) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 51) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 52) chain B residue 126 type sequence N description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 53) chain B residue 127 type sequence S description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 54) chain C residue 69 type sequence K description BINDING SITE FOR RESIDUE S1S A 1701 source : AC6 55) chain B residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 56) chain C residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 57) chain C residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 58) chain C residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 59) chain C residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 60) chain C residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 61) chain C residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 62) chain C residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 63) chain C residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 64) chain C residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 65) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S C 2201 source : AC7 66) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 67) chain A residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 68) chain D residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 69) chain D residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 70) chain D residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 71) chain D residue 106 type sequence Q description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 72) chain D residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 73) chain D residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 74) chain D residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 75) chain D residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 76) chain D residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 77) chain D residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S D 2301 source : AC8 78) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 79) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 80) chain C residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 81) chain C residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 82) chain C residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 83) chain C residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 84) chain D residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 85) chain D residue 122 type sequence V description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 86) chain D residue 124 type sequence K description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 87) chain D residue 125 type sequence F description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 88) chain D residue 130 type sequence E description BINDING SITE FOR RESIDUE S1S C 2401 source : AC9 89) chain B residue 112 type sequence R description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 90) chain C residue 115 type sequence A description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 91) chain C residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 92) chain D residue 126 type sequence N description BINDING SITE FOR RESIDUE S1S C 2501 source : BC1 93) chain A residue 62 type sequence F description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 94) chain A residue 64 type sequence K description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 95) chain A residue 65 type sequence I description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 96) chain A residue 66 type sequence P description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 97) chain C residue 87 type sequence E description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 98) chain C residue 93 type sequence G description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 99) chain C residue 95 type sequence F description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 100) chain C residue 118 type sequence Y description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 101) chain D residue 127 type sequence S description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 102) chain D residue 128 type sequence L description BINDING SITE FOR RESIDUE S1S C 2601 source : BC2 103) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 104) chain C residue 58 type sequence H description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 105) chain C residue 61 type sequence F description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 106) chain D residue 126 type sequence N description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 107) chain D residue 127 type sequence S description BINDING SITE FOR RESIDUE S1S D 2701 source : BC3 108) chain A residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 109) chain B residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 110) chain C residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 111) chain D residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

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