eF-site ID 2aoa-B PDB Code 2aoa Chain B click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source null (GRB2_HUMAN) Sequence B:  AKAEEMLSKQRHDGAFLIREGDFSLSVKFGNDVQHFKVLR DGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLR Description Functional site 1) chain B residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 2) chain B residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 3) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 4) chain B residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 5) chain B residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 6) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 7) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 8) chain B residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 9) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 10) chain B residue 94 type sequence D description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 11) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 12) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 13) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 14) chain B residue 122 type sequence V description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 15) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 16) chain B residue 130 type sequence E description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 17) chain B residue 112 type sequence R description BINDING SITE FOR RESIDUE P33 B 501 source : AC4 18) chain B residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

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