eF-site ID 2aoa-AB PDB Code 2aoa Chain A, B click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source Homo sapiens (Human) (GRB2_HUMAN) Sequence A:  HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSL SVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRS TSVSRNQQIFLRD B:  AKAEEMLSKQRHDGAFLIREGDFSLSVKFGNDVQHFKVLR DGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLR Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 2) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 4) chain A residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 6) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 7) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 8) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 9) chain A residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 10) chain A residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 11) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 12) chain B residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 13) chain A residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 14) chain B residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 15) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 16) chain B residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 17) chain B residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 18) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 19) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 20) chain B residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 21) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 22) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 23) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 24) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 25) chain B residue 94 type sequence D description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 26) chain B residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 27) chain B residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 28) chain B residue 121 type sequence W description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 29) chain B residue 122 type sequence V description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 30) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 31) chain B residue 130 type sequence E description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 32) chain B residue 112 type sequence R description BINDING SITE FOR RESIDUE P33 B 501 source : AC4 33) chain A residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

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