eF-site ID 2aoa-A PDB Code 2aoa Chain A click to enlarge Title Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Classification TRANSFERASE Compound Growth factor receptor-bound protein 2 Source null (GRB2_HUMAN) Sequence A:  HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSL SVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRS TSVSRNQQIFLRD Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 2) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 4) chain A residue 89 type sequence E description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 6) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 7) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 8) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 9) chain A residue 109 type sequence K description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 10) chain A residue 111 type sequence L description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 11) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE S1S A 201 source : AC1 12) chain A residue 143 type sequence N description BINDING SITE FOR RESIDUE S1S B 301 source : AC2 13) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 14) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 15) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE S1S A 401 source : AC3 16) chain A residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

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