eF-site ID 2amb-A
PDB Code 2amb
Chain A

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Title Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone
Classification Hormone/Growth Factor Receptor
Compound Androgen receptor
Source null (ANDR_HUMAN)
Sequence A:  PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGER
QLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMG
WRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHL
SQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDEL
RMNYIKELDRIIACKRTSCSRRFYQLTKLLDSVQPIAREL
HQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKP
IYFHTQ
Description


Functional site
1) chain A
residue 696
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 1002
source : AC1
2) chain A
residue 697
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 1002
source : AC1
3) chain A
residue 777
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 1002
source : AC1
4) chain A
residue 779
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1002
source : AC1
5) chain A
residue 853
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 1002
source : AC1
6) chain A
residue 704
type
sequence L
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
7) chain A
residue 705
type
sequence N
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
8) chain A
residue 707
type
sequence L
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
9) chain A
residue 711
type
sequence Q
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
10) chain A
residue 741
type
sequence W
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
11) chain A
residue 745
type
sequence M
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
12) chain A
residue 749
type
sequence M
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
13) chain A
residue 752
type
sequence R
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
14) chain A
residue 877
type
sequence T
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
15) chain A
residue 880
type
sequence L
description BINDING SITE FOR RESIDUE 17H A 1001
source : AC2
16) chain A
residue 686
type
sequence C
description BINDING SITE FOR RESIDUE DTT A 1003
source : AC3
17) chain A
residue 766
type
sequence P
description BINDING SITE FOR RESIDUE DTT A 1003
source : AC3
18) chain A
residue 798
type
sequence Q
description BINDING SITE FOR RESIDUE DTT A 1003
source : AC3
19) chain A
residue 799
type
sequence I
description BINDING SITE FOR RESIDUE DTT A 1003
source : AC3
20) chain A
residue 800
type
sequence T
description BINDING SITE FOR RESIDUE DTT A 1003
source : AC3
21) chain A
residue 789
type
sequence H
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
22) chain A
residue 796
type
sequence W
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
23) chain A
residue 821
type
sequence L
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
24) chain A
residue 822
type
sequence K
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
25) chain A
residue 823
type
sequence N
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
26) chain A
residue 824
type
sequence Q
description BINDING SITE FOR RESIDUE EPE A 1004
source : AC4
27) chain A
residue 682
type
sequence P
description BINDING SITE FOR RESIDUE GOL A 1005
source : AC5
28) chain A
residue 711
type
sequence Q
description BINDING SITE FOR RESIDUE GOL A 1005
source : AC5
29) chain A
residue 745
type
sequence M
description BINDING SITE FOR RESIDUE GOL A 1005
source : AC5
30) chain A
residue 752
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 1005
source : AC5
31) chain A
residue 846
type CROSSLNK
sequence R
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19345326
source Swiss-Prot : SWS_FT_FI6
32) chain A
residue 721
type SITE
sequence A
description Interaction with coactivator LXXL and FXXFY motifs => ECO:0000269|PubMed:25091737
source Swiss-Prot : SWS_FT_FI3
33) chain A
residue 898
type SITE
sequence I
description Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000269|PubMed:25091737
source Swiss-Prot : SWS_FT_FI4
34) chain A
residue 916
type MOD_RES
sequence F
description Phosphotyrosine; by CSK => ECO:0000269|PubMed:17045208
source Swiss-Prot : SWS_FT_FI5
35) chain A
residue 706
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2AMB, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2PNU, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
source Swiss-Prot : SWS_FT_FI1
36) chain A
residue 878
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
source Swiss-Prot : SWS_FT_FI2
37) chain A
residue 753
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
source Swiss-Prot : SWS_FT_FI2

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