|
eF-site ID
|
2amb-A |
PDB Code
|
2amb |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone |
Classification
|
Hormone/Growth Factor Receptor |
Compound
|
Androgen receptor |
Source
|
Homo sapiens (Human) (ANDR_HUMAN) |
|
Sequence
|
A: |
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGER
QLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMG
WRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHL
SQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDEL
RMNYIKELDRIIACKRTSCSRRFYQLTKLLDSVQPIAREL
HQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKP
IYFHTQ
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
696 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE SO4 A 1002
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
697 |
type |
|
sequence |
F
|
description |
BINDING SITE FOR RESIDUE SO4 A 1002
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
777 |
type |
|
sequence |
K
|
description |
BINDING SITE FOR RESIDUE SO4 A 1002
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
779 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE SO4 A 1002
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
853 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE SO4 A 1002
|
source |
: AC1
|
|
6)
|
chain |
A |
residue |
704 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
705 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
707 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
711 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
10)
|
chain |
A |
residue |
741 |
type |
|
sequence |
W
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
11)
|
chain |
A |
residue |
745 |
type |
|
sequence |
M
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
12)
|
chain |
A |
residue |
749 |
type |
|
sequence |
M
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
13)
|
chain |
A |
residue |
752 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
14)
|
chain |
A |
residue |
877 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
15)
|
chain |
A |
residue |
880 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE 17H A 1001
|
source |
: AC2
|
|
16)
|
chain |
A |
residue |
686 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE DTT A 1003
|
source |
: AC3
|
|
17)
|
chain |
A |
residue |
766 |
type |
|
sequence |
P
|
description |
BINDING SITE FOR RESIDUE DTT A 1003
|
source |
: AC3
|
|
18)
|
chain |
A |
residue |
798 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE DTT A 1003
|
source |
: AC3
|
|
19)
|
chain |
A |
residue |
799 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE DTT A 1003
|
source |
: AC3
|
|
20)
|
chain |
A |
residue |
800 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE DTT A 1003
|
source |
: AC3
|
|
21)
|
chain |
A |
residue |
789 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
22)
|
chain |
A |
residue |
796 |
type |
|
sequence |
W
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
23)
|
chain |
A |
residue |
821 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
24)
|
chain |
A |
residue |
822 |
type |
|
sequence |
K
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
25)
|
chain |
A |
residue |
823 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
26)
|
chain |
A |
residue |
824 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE EPE A 1004
|
source |
: AC4
|
|
27)
|
chain |
A |
residue |
682 |
type |
|
sequence |
P
|
description |
BINDING SITE FOR RESIDUE GOL A 1005
|
source |
: AC5
|
|
28)
|
chain |
A |
residue |
711 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE GOL A 1005
|
source |
: AC5
|
|
29)
|
chain |
A |
residue |
745 |
type |
|
sequence |
M
|
description |
BINDING SITE FOR RESIDUE GOL A 1005
|
source |
: AC5
|
|
30)
|
chain |
A |
residue |
752 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE GOL A 1005
|
source |
: AC5
|
|
31)
|
chain |
A |
residue |
706 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2AMB, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2PNU, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
32)
|
chain |
A |
residue |
753 |
type |
BINDING |
sequence |
S
|
description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
33)
|
chain |
A |
residue |
878 |
type |
BINDING |
sequence |
F
|
description |
BINDING => ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:16641486, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:25091737, ECO:0007744|PDB:1T5Z, ECO:0007744|PDB:1T63, ECO:0007744|PDB:1T65, ECO:0007744|PDB:1XJ7, ECO:0007744|PDB:2AM9, ECO:0007744|PDB:2AMA, ECO:0007744|PDB:2PIO, ECO:0007744|PDB:2PIP, ECO:0007744|PDB:2PIQ, ECO:0007744|PDB:2PIR, ECO:0007744|PDB:2PIT, ECO:0007744|PDB:2PIU, ECO:0007744|PDB:2PIV, ECO:0007744|PDB:2PIW, ECO:0007744|PDB:2PIX, ECO:0007744|PDB:2PKL, ECO:0007744|PDB:2Q7I, ECO:0007744|PDB:2Q7J, ECO:0007744|PDB:2Q7K, ECO:0007744|PDB:2Q7L, ECO:0007744|PDB:2YHD, ECO:0007744|PDB:2YLO, ECO:0007744|PDB:2YLP, ECO:0007744|PDB:2YLQ, ECO:0007744|PDB:2Z4J, ECO:0007744|PDB:3L3X, ECO:0007744|PDB:3L3Z, ECO:0007744|PDB:3ZQT, ECO:0007744|PDB:4HLW, ECO:0007744|PDB:4K7A, ECO:0007744|PDB:4OEA, ECO:0007744|PDB:4OED, ECO:0007744|PDB:4OEY, ECO:0007744|PDB:4OEZ, ECO:0007744|PDB:4OFR, ECO:0007744|PDB:4OFU, ECO:0007744|PDB:5JJM
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
34)
|
chain |
A |
residue |
721 |
type |
SITE |
sequence |
A
|
description |
Interaction with coactivator LXXL and FXXFY motifs => ECO:0000269|PubMed:25091737
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
35)
|
chain |
A |
residue |
898 |
type |
SITE |
sequence |
I
|
description |
Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000269|PubMed:25091737
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
36)
|
chain |
A |
residue |
916 |
type |
MOD_RES |
sequence |
F
|
description |
Phosphotyrosine; by CSK => ECO:0000269|PubMed:17045208
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
37)
|
chain |
A |
residue |
846 |
type |
CROSSLNK |
sequence |
R
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19345326
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|