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eF-site ID
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2ajq-F |
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PDB Code
|
2ajq |
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Chain
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F |
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click to enlarge
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Title
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Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing |
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Classification
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TRANSFERASE,TRANSCRIPTION/DNA |
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Compound
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DNA Primer |
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Source
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Enterobacteria phage T7 (Bacteriophage T7) (2AJQ) |
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Sequence
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F: |
MIVSAIAANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG
AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE
FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGKRF
GSHALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEW
WNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTD
VGYTTFWSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIE
ELYVELAARRSELLRKLTETFGSWYQPKGGTEMFCHPRTG
KPLPKYPRIKTPKVGGIFKLDTREYVAGAPYTPVEHVVFN
PSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLEGVRVD
DPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGK
IHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAF
GAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFDNGE
YAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLYGAGDE
KIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLVE
SSQWVAGEQQVKWKRRWIKGLDGRKVHVRSPHAALNTLLQ
SAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDE
IQVGCRTEEIAQVVIETAQEAMRWVGDHWNFRCLLDTEGK
MGPNWAICH
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Description
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Functional site
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|
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1)
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chain |
F |
| residue |
7 |
| type |
ACT_SITE |
| sequence |
A
|
| description |
Nucleophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
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chain |
F |
| residue |
174 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Nucleophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
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chain |
F |
| residue |
475 |
| type |
SITE |
| sequence |
D
|
| description |
Deprotonates C-terminal active site Cys
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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4)
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chain |
F |
| residue |
476 |
| type |
SITE |
| sequence |
A
|
| description |
Deprotonates C-terminal active site Cys
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
F |
| residue |
654 |
| type |
SITE |
| sequence |
D
|
| description |
Deprotonates C-terminal active site Cys
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
F |
| residue |
506 |
| type |
SITE |
| sequence |
H
|
| description |
Contributes to redox potential value
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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7)
|
chain |
F |
| residue |
518 |
| type |
SITE |
| sequence |
R
|
| description |
Contributes to redox potential value
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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8)
|
chain |
F |
| residue |
522 |
| type |
SITE |
| sequence |
K
|
| description |
Contributes to redox potential value
|
| source |
Swiss-Prot : SWS_FT_FI3
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|
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9)
|
chain |
F |
| residue |
526 |
| type |
SITE |
| sequence |
Y
|
| description |
Contributes to redox potential value
|
| source |
Swiss-Prot : SWS_FT_FI3
|
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