eF-site ID 2ajq-ABFI PDB Code 2ajq Chain A, B, F, I click to enlarge Title Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing Classification TRANSFERASE,TRANSCRIPTION/DNA Compound DNA Primer Source null (2AJQ) Sequence A:  MIVSAIAANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGKRF GSHALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEW WNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTD VGYTTFWSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIE ELYVELAARRSELLRKLTETFGSWYQPKGGTEMFCHPRTG KPLPKYPRIKTPKVGGIFKKPKNKAQREGREPCELDTREY VAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKG APVVDDEVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSA EGDKAWLRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQI PGVRSPYGEQCRAAFGAEHHLDGITGKPWVQAGIDASGLE LRCLAHFMARFDNGEYAHEILNGDIHTKNQIAAELPTRDN AKTFIYGFLYGAGDEKIGQIVGAGKERGKELKKKFLENTP AIAALRESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRK VHVRSPHAALNTLLQSAGALICKLWIIKTEEMLVEKGLKH GWDGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRWV GDHWNFRCLLDTEGKMGPNWAICH B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL F:  MIVSAIAANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGKRF GSHALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEW WNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTD VGYTTFWSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIE ELYVELAARRSELLRKLTETFGSWYQPKGGTEMFCHPRTG KPLPKYPRIKTPKVGGIFKLDTREYVAGAPYTPVEHVVFN PSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLEGVRVD DPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGK IHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAF GAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFDNGE YAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLYGAGDE KIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLVE SSQWVAGEQQVKWKRRWIKGLDGRKVHVRSPHAALNTLLQ SAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDE IQVGCRTEEIAQVVIETAQEAMRWVGDHWNFRCLLDTEGK MGPNWAICH I:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL Description Functional site 1) chain B residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 2) chain I residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 3) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447 4) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 5) chain B residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 6) chain B residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 7) chain I residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 8) chain I residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 9) chain F residue 7 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 10) chain F residue 174 type ACT_SITE sequence D description Nucleophile source Swiss-Prot : SWS_FT_FI1 11) chain B residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 12) chain I residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 13) chain A residue 654 type SITE sequence D description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 14) chain F residue 475 type SITE sequence D description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 15) chain F residue 476 type SITE sequence A description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 16) chain F residue 654 type SITE sequence D description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 17) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 18) chain B residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 19) chain I residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 20) chain I residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 21) chain F residue 506 type SITE sequence H description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 22) chain F residue 518 type SITE sequence R description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 23) chain F residue 522 type SITE sequence K description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 24) chain F residue 526 type SITE sequence Y description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3

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