eF-site ID 2abz-A PDB Code 2abz Chain A click to enlarge Title Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A Classification hydrolase/hydrolase inhibitor Compound Carboxypeptidase A1 Source null (MCPI_HIRME) Sequence A:  TNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYE GRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFA KKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQN RLWRKTRSVSLCVGVDANRNWDAGFGKAGASSSPCSETYH GKYANSEVEVKSIVDFVKDHGNFKAFLSIHSYSQLLLYPY GYTTQSIPDKTELNQVAKSAVAALKSLYGTSYKYGSIITT IYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQI IPTAQETWLGVLTIMEHTV Description Functional site 1) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 2) chain A residue 72 type sequence E description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 3) chain A residue 196 type sequence H description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 4) chain A residue 127 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 144 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 197 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI3 7) chain A residue 248 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 69 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 72 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 196 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 60-82 type prosite sequence PAIWIDLGIHSREWITQATGVWF description CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIwIdlGiHSrEwITQatgvwF source prosite : PS00132 12) chain A residue 196-206 type prosite sequence HSYSQLLLYPY description CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLlYPY source prosite : PS00133 13) chain A residue 69 type catalytic sequence H description 171 source MCSA : MCSA1 14) chain A residue 72 type catalytic sequence E description 171 source MCSA : MCSA1 15) chain A residue 127 type catalytic sequence R description 171 source MCSA : MCSA1 16) chain A residue 196 type catalytic sequence H description 171 source MCSA : MCSA1 17) chain A residue 270 type catalytic sequence E description 171 source MCSA : MCSA1 18) chain A residue 270 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 source Swiss-Prot : SWS_FT_FI1

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