eF-site ID 2a69-P PDB Code 2a69 Chain P click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence P:  KISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAI KKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDP KTVEEIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLR LVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRF KFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSR TARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQE PVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEE LEKALSKLSEREAMVLKLRKGLIDGEEVGAFFGVTRERIR QIENKALRKLKYHESRTRKLRDFLD Description Functional site 1) chain P residue 241 type sequence W description BINDING SITE FOR RESIDUE MG C 9065 source : HC1 2) chain P residue 149 type sequence E description BINDING SITE FOR RESIDUE MG D 9039 source : NC1 3) chain P residue 374 type sequence G description BINDING SITE FOR RESIDUE MG M 9196 source : BD3 4) chain P residue 421 type sequence F description BINDING SITE FOR RESIDUE MG M 9208 source : BD7 5) chain P residue 340 type sequence S description BINDING SITE FOR RESIDUE MG P 9189 source : QD5 6) chain P residue 82 type sequence R description BINDING SITE FOR RESIDUE MG P 9202 source : QD6 7) chain P residue 165 type sequence S description BINDING SITE FOR RESIDUE MG P 9209 source : QD7 8) chain P residue 349 type sequence L description BINDING SITE FOR RESIDUE MG P 9226 source : QD9 9) chain P residue 417 type sequence K description BINDING SITE FOR RESIDUE MG P 9228 source : RD1 10) chain P residue 418 type sequence L description BINDING SITE FOR RESIDUE MG P 9228 source : RD1 11) chain P residue 419 type sequence R description BINDING SITE FOR RESIDUE MG P 9228 source : RD1 12) chain P residue 420 type sequence D description BINDING SITE FOR RESIDUE MG P 9228 source : RD1 13) chain P residue 205 type sequence R description BINDING SITE FOR RESIDUE MG P 9255 source : RD3 14) chain P residue 228 type sequence E description BINDING SITE FOR RESIDUE MG P 9277 source : RD4 15) chain P residue 273 type sequence R description BINDING SITE FOR RESIDUE MG P 9280 source : RD5 16) chain P residue 277 type sequence Q description BINDING SITE FOR RESIDUE MG P 9285 source : RD6 17) chain P residue 280 type sequence Q description BINDING SITE FOR RESIDUE MG P 9285 source : RD6 18) chain P residue 403 type sequence K description BINDING SITE FOR RESIDUE MG P 9297 source : RD7 19) chain P residue 407 type sequence K description BINDING SITE FOR RESIDUE MG P 9297 source : RD7 20) chain P residue 82 type sequence R description BINDING SITE FOR RESIDUE MG P 9325 source : RD9 21) chain P residue 364 type sequence R description BINDING SITE FOR RESIDUE MG P 9399 source : SD1 22) chain P residue 390 type sequence F description BINDING SITE FOR RESIDUE MG P 9399 source : SD1 23) chain P residue 359 type sequence S description BINDING SITE FOR RESIDUE MG P 9436 source : SD2 24) chain P residue 361 type sequence L description BINDING SITE FOR RESIDUE MG P 9436 source : SD2 25) chain P residue 362 type sequence S description BINDING SITE FOR RESIDUE MG P 9436 source : SD2

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