eF-site ID 2a69-N PDB Code 2a69 Chain N click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence N:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA Description Functional site 1) chain N residue 65 type sequence R description BINDING SITE FOR RESIDUE MG M 9196 source : BD3 2) chain N residue 651 type sequence E description BINDING SITE FOR RESIDUE MG M 9205 source : BD6 3) chain N residue 1463 type sequence K description BINDING SITE FOR RESIDUE MG M 9268 source : ED2 4) chain N residue 630 type sequence V description BINDING SITE FOR RESIDUE MG M 9299 source : ED6 5) chain N residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN N 7059 source : HD4 6) chain N residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN N 7059 source : HD4 7) chain N residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN N 7059 source : HD4 8) chain N residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN N 7059 source : HD4 9) chain N residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN N 7113 source : HD5 10) chain N residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN N 7113 source : HD5 11) chain N residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN N 7113 source : HD5 12) chain N residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN N 7113 source : HD5 13) chain N residue 920 type sequence L description BINDING SITE FOR RESIDUE MG N 9179 source : HD6 14) chain N residue 1212 type sequence A description BINDING SITE FOR RESIDUE MG N 9179 source : HD6 15) chain N residue 1213 type sequence R description BINDING SITE FOR RESIDUE MG N 9179 source : HD6 16) chain N residue 1196 type sequence T description BINDING SITE FOR RESIDUE MG N 9181 source : HD7 17) chain N residue 1197 type sequence R description BINDING SITE FOR RESIDUE MG N 9181 source : HD7 18) chain N residue 786 type sequence I description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 19) chain N residue 906 type sequence Q description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 20) chain N residue 907 type sequence E description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 21) chain N residue 908 type sequence K description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 22) chain N residue 1026 type sequence S description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 23) chain N residue 1027 type sequence G description BINDING SITE FOR RESIDUE MG N 9184 source : HD8 24) chain N residue 1130 type sequence R description BINDING SITE FOR RESIDUE MG N 9186 source : ID1 25) chain N residue 1131 type sequence S description BINDING SITE FOR RESIDUE MG N 9186 source : ID1 26) chain N residue 1132 type sequence L description BINDING SITE FOR RESIDUE MG N 9186 source : ID1 27) chain N residue 143 type sequence N description BINDING SITE FOR RESIDUE MG N 9192 source : ID3 28) chain N residue 144 type sequence G description BINDING SITE FOR RESIDUE MG N 9192 source : ID3 29) chain N residue 145 type sequence V description BINDING SITE FOR RESIDUE MG N 9192 source : ID3 30) chain N residue 961 type sequence K description BINDING SITE FOR RESIDUE MG N 9193 source : ID4 31) chain N residue 251 type sequence F description BINDING SITE FOR RESIDUE MG N 9194 source : ID5 32) chain N residue 1390 type sequence L description BINDING SITE FOR RESIDUE MG N 9199 source : ID6 33) chain N residue 1391 type sequence E description BINDING SITE FOR RESIDUE MG N 9199 source : ID6 34) chain N residue 107 type sequence D description BINDING SITE FOR RESIDUE MG N 9200 source : ID7 35) chain N residue 109 type sequence P description BINDING SITE FOR RESIDUE MG N 9200 source : ID7 36) chain N residue 111 type sequence K description BINDING SITE FOR RESIDUE MG N 9200 source : ID7 37) chain N residue 1359 type sequence Q description BINDING SITE FOR RESIDUE MG N 9206 source : ID8 38) chain N residue 1439 type sequence S description BINDING SITE FOR RESIDUE MG N 9207 source : ID9 39) chain N residue 1443 type sequence T description BINDING SITE FOR RESIDUE MG N 9207 source : ID9 40) chain N residue 706 type sequence P description BINDING SITE FOR RESIDUE MG N 9211 source : JD1 41) chain N residue 736 type sequence F description BINDING SITE FOR RESIDUE MG N 9211 source : JD1 42) chain N residue 737 type sequence N description BINDING SITE FOR RESIDUE MG N 9211 source : JD1 43) chain N residue 1197 type sequence R description BINDING SITE FOR RESIDUE MG N 9214 source : JD2 44) chain N residue 1373 type sequence R description BINDING SITE FOR RESIDUE MG N 9214 source : JD2 45) chain N residue 1374 type sequence Q description BINDING SITE FOR RESIDUE MG N 9214 source : JD2 46) chain N residue 1377 type sequence K description BINDING SITE FOR RESIDUE MG N 9214 source : JD2 47) chain N residue 188 type sequence G description BINDING SITE FOR RESIDUE MG N 9215 source : JD3 48) chain N residue 441 type sequence R description BINDING SITE FOR RESIDUE MG N 9215 source : JD3 49) chain N residue 1116 type sequence N description BINDING SITE FOR RESIDUE MG N 9217 source : JD4 50) chain N residue 1096 type sequence R description BINDING SITE FOR RESIDUE MG N 9221 source : JD5 51) chain N residue 183 type sequence E description BINDING SITE FOR RESIDUE MG N 9229 source : JD6 52) chain N residue 187 type sequence K description BINDING SITE FOR RESIDUE MG N 9229 source : JD6 53) chain N residue 965 type sequence E description BINDING SITE FOR RESIDUE MG N 9231 source : JD7 54) chain N residue 1196 type sequence T description BINDING SITE FOR RESIDUE MG N 9232 source : JD8 55) chain N residue 1235 type sequence Q description BINDING SITE FOR RESIDUE MG N 9233 source : JD9 56) chain N residue 1237 type sequence T description BINDING SITE FOR RESIDUE MG N 9233 source : JD9 57) chain N residue 530 type sequence V description BINDING SITE FOR RESIDUE MG N 9236 source : KD1 58) chain N residue 531 type sequence D description BINDING SITE FOR RESIDUE MG N 9236 source : KD1 59) chain N residue 532 type sequence G description BINDING SITE FOR RESIDUE MG N 9236 source : KD1 60) chain N residue 772 type sequence P description BINDING SITE FOR RESIDUE MG N 9238 source : KD2 61) chain N residue 1208 type sequence D description BINDING SITE FOR RESIDUE MG N 9238 source : KD2 62) chain N residue 1367 type sequence H description BINDING SITE FOR RESIDUE MG N 9238 source : KD2 63) chain N residue 1468 type sequence L description BINDING SITE FOR RESIDUE MG N 9240 source : KD3 64) chain N residue 133 type sequence I description BINDING SITE FOR RESIDUE MG N 9243 source : KD4 65) chain N residue 135 type sequence L description BINDING SITE FOR RESIDUE MG N 9243 source : KD4 66) chain N residue 151 type sequence Q description BINDING SITE FOR RESIDUE MG N 9243 source : KD4 67) chain N residue 153 type sequence L description BINDING SITE FOR RESIDUE MG N 9243 source : KD4 68) chain N residue 1431 type sequence T description BINDING SITE FOR RESIDUE MG N 9249 source : KD5 69) chain N residue 1432 type sequence K description BINDING SITE FOR RESIDUE MG N 9249 source : KD5 70) chain N residue 187 type sequence K description BINDING SITE FOR RESIDUE MG N 9259 source : KD6 71) chain N residue 441 type sequence R description BINDING SITE FOR RESIDUE MG N 9259 source : KD6 72) chain N residue 1165 type sequence Y description BINDING SITE FOR RESIDUE MG N 9267 source : KD8 73) chain N residue 1501 type sequence E description BINDING SITE FOR RESIDUE MG N 9269 source : KD9 74) chain N residue 1502 type sequence A description BINDING SITE FOR RESIDUE MG N 9269 source : KD9 75) chain N residue 1416 type sequence A description BINDING SITE FOR RESIDUE MG N 9270 source : LD1 76) chain N residue 1417 type sequence W description BINDING SITE FOR RESIDUE MG N 9270 source : LD1 77) chain N residue 576 type sequence E description BINDING SITE FOR RESIDUE MG N 9271 source : LD2 78) chain N residue 579 type sequence D description BINDING SITE FOR RESIDUE MG N 9271 source : LD2 79) chain N residue 580 type sequence A description BINDING SITE FOR RESIDUE MG N 9271 source : LD2 80) chain N residue 583 type sequence D description BINDING SITE FOR RESIDUE MG N 9271 source : LD2 81) chain N residue 587 type sequence R description BINDING SITE FOR RESIDUE MG N 9271 source : LD2 82) chain N residue 1266 type sequence R description BINDING SITE FOR RESIDUE MG N 9274 source : LD3 83) chain N residue 494 type sequence K description BINDING SITE FOR RESIDUE MG N 9276 source : LD4 84) chain N residue 1318 type sequence Y description BINDING SITE FOR RESIDUE MG N 9286 source : LD5 85) chain N residue 811 type sequence E description BINDING SITE FOR RESIDUE MG N 9287 source : LD6 86) chain N residue 157 type sequence E description BINDING SITE FOR RESIDUE MG N 9288 source : LD7 87) chain N residue 1033 type sequence Q description BINDING SITE FOR RESIDUE MG N 9292 source : LD8 88) chain N residue 139 type sequence G description BINDING SITE FOR RESIDUE MG N 9298 source : MD1 89) chain N residue 140 type sequence A description BINDING SITE FOR RESIDUE MG N 9298 source : MD1 90) chain N residue 141 type sequence I description BINDING SITE FOR RESIDUE MG N 9298 source : MD1 91) chain N residue 146 type sequence P description BINDING SITE FOR RESIDUE MG N 9298 source : MD1 92) chain N residue 147 type sequence V description BINDING SITE FOR RESIDUE MG N 9298 source : MD1 93) chain N residue 529 type sequence Q description BINDING SITE FOR RESIDUE MG N 9302 source : MD2 94) chain N residue 1327 type sequence R description BINDING SITE FOR RESIDUE MG N 9303 source : MD3 95) chain N residue 488 type sequence R description BINDING SITE FOR RESIDUE MG N 9304 source : MD4 96) chain N residue 1242 type sequence H description BINDING SITE FOR RESIDUE MG N 9313 source : MD6 97) chain N residue 213 type sequence V description BINDING SITE FOR RESIDUE MG N 9316 source : MD7 98) chain N residue 390 type sequence P description BINDING SITE FOR RESIDUE MG N 9316 source : MD7 99) chain N residue 1116 type sequence N description BINDING SITE FOR RESIDUE MG N 9317 source : MD8 100) chain N residue 403 type sequence F description BINDING SITE FOR RESIDUE MG N 9318 source : MD9 101) chain N residue 1419 type sequence P description BINDING SITE FOR RESIDUE MG N 9322 source : ND1 102) chain N residue 921 type sequence R description BINDING SITE FOR RESIDUE MG N 9323 source : ND2 103) chain N residue 466 type sequence K description BINDING SITE FOR RESIDUE MG N 9326 source : ND3 104) chain N residue 187 type sequence K description BINDING SITE FOR RESIDUE MG N 9327 source : ND4 105) chain N residue 113 type sequence G description BINDING SITE FOR RESIDUE MG N 9398 source : ND5 106) chain N residue 116 type sequence L description BINDING SITE FOR RESIDUE MG N 9398 source : ND5 107) chain N residue 118 type sequence L description BINDING SITE FOR RESIDUE MG N 9398 source : ND5 108) chain N residue 119 type sequence S description BINDING SITE FOR RESIDUE MG N 9398 source : ND5 109) chain N residue 120 type sequence A description BINDING SITE FOR RESIDUE MG N 9398 source : ND5 110) chain N residue 484 type sequence P description BINDING SITE FOR RESIDUE MG N 9402 source : ND6 111) chain N residue 485 type sequence S description BINDING SITE FOR RESIDUE MG N 9402 source : ND6 112) chain N residue 488 type sequence R description BINDING SITE FOR RESIDUE MG N 9402 source : ND6 113) chain N residue 6 type sequence R description BINDING SITE FOR RESIDUE MG N 9415 source : ND7 114) chain N residue 1482 type sequence R description BINDING SITE FOR RESIDUE MG N 9415 source : ND7 115) chain N residue 1048 type sequence P description BINDING SITE FOR RESIDUE MG N 9417 source : ND8 116) chain N residue 901 type sequence Q description BINDING SITE FOR RESIDUE MG N 9418 source : ND9 117) chain N residue 684 type sequence K description BINDING SITE FOR RESIDUE MG N 9419 source : OD1 118) chain N residue 686 type sequence E description BINDING SITE FOR RESIDUE MG N 9419 source : OD1 119) chain N residue 903 type sequence D description BINDING SITE FOR RESIDUE MG N 9426 source : OD4 120) chain N residue 238 type sequence P description BINDING SITE FOR RESIDUE MG N 9429 source : OD7 121) chain N residue 240 type sequence E description BINDING SITE FOR RESIDUE MG N 9429 source : OD7 122) chain N residue 1252 type sequence I description BINDING SITE FOR RESIDUE MG N 9430 source : OD8 123) chain N residue 196 type sequence V description BINDING SITE FOR RESIDUE MG N 9448 source : OD9 124) chain N residue 204 type sequence L description BINDING SITE FOR RESIDUE MG N 9449 source : PD1 125) chain N residue 1058 type sequence R description BINDING SITE FOR RESIDUE MG N 9450 source : PD2 126) chain N residue 872 type sequence R description BINDING SITE FOR RESIDUE MG N 9465 source : PD3 127) chain N residue 11 type sequence A description BINDING SITE FOR RESIDUE MG N 9467 source : PD4 128) chain N residue 12 type sequence L description BINDING SITE FOR RESIDUE MG N 9467 source : PD4 129) chain N residue 104 type sequence F description BINDING SITE FOR RESIDUE MG N 9467 source : PD4 130) chain N residue 1451 type sequence A description BINDING SITE FOR RESIDUE MG N 9467 source : PD4 131) chain N residue 527 type sequence M description BINDING SITE FOR RESIDUE MG N 9473 source : PD6 132) chain N residue 529 type sequence Q description BINDING SITE FOR RESIDUE MG N 9484 source : PD7 133) chain N residue 640 type sequence H description BINDING SITE FOR RESIDUE MG O 9266 source : QD2 134) chain N residue 669 type sequence N description BINDING SITE FOR RESIDUE MG P 9228 source : RD1 135) chain N residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 136) chain N residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 137) chain N residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 138) chain N residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 139) chain N residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 140) chain N residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 141) chain N residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 142) chain N residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 143) chain N residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 144) chain N residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 145) chain N residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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