eF-site ID 2a69-M PDB Code 2a69 Chain M click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence M:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR Description Functional site 1) chain M residue 134 type sequence R description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 2) chain M residue 389 type sequence S description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 3) chain M residue 390 type sequence Q description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 4) chain M residue 392 type sequence S description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 5) chain M residue 393 type sequence Q description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 6) chain M residue 394 type sequence F description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 7) chain M residue 395 type sequence K description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 8) chain M residue 396 type sequence D description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 9) chain M residue 406 type sequence H description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 10) chain M residue 409 type sequence R description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 11) chain M residue 411 type sequence S description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 12) chain M residue 413 type sequence L description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 13) chain M residue 444 type sequence P description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 14) chain M residue 452 type sequence I description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 15) chain M residue 1000 type sequence M description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 16) chain M residue 1002 type sequence E description BINDING SITE FOR RESIDUE RPT M 8002 source : AD9 17) chain M residue 448 type sequence N description BINDING SITE FOR RESIDUE MG M 9190 source : BD1 18) chain M residue 1116 type sequence A description BINDING SITE FOR RESIDUE MG M 9195 source : BD2 19) chain M residue 769 type sequence P description BINDING SITE FOR RESIDUE MG M 9196 source : BD3 20) chain M residue 770 type sequence E description BINDING SITE FOR RESIDUE MG M 9196 source : BD3 21) chain M residue 951 type sequence G description BINDING SITE FOR RESIDUE MG M 9201 source : BD4 22) chain M residue 952 type sequence L description BINDING SITE FOR RESIDUE MG M 9201 source : BD4 23) chain M residue 969 type sequence Q description BINDING SITE FOR RESIDUE MG M 9201 source : BD4 24) chain M residue 219 type sequence Q description BINDING SITE FOR RESIDUE MG M 9203 source : BD5 25) chain M residue 220 type sequence G description BINDING SITE FOR RESIDUE MG M 9203 source : BD5 26) chain M residue 1010 type sequence T description BINDING SITE FOR RESIDUE MG M 9205 source : BD6 27) chain M residue 1026 type sequence Q description BINDING SITE FOR RESIDUE MG M 9205 source : BD6 28) chain M residue 775 type sequence R description BINDING SITE FOR RESIDUE MG M 9208 source : BD7 29) chain M residue 714 type sequence D description BINDING SITE FOR RESIDUE MG M 9210 source : BD8 30) chain M residue 820 type sequence R description BINDING SITE FOR RESIDUE MG M 9210 source : BD8 31) chain M residue 332 type sequence R description BINDING SITE FOR RESIDUE MG M 9212 source : BD9 32) chain M residue 464 type sequence L description BINDING SITE FOR RESIDUE MG M 9212 source : BD9 33) chain M residue 465 type sequence G description BINDING SITE FOR RESIDUE MG M 9212 source : BD9 34) chain M residue 466 type sequence F description BINDING SITE FOR RESIDUE MG M 9212 source : BD9 35) chain M residue 204 type sequence Q description BINDING SITE FOR RESIDUE MG M 9219 source : CD1 36) chain M residue 222 type sequence M description BINDING SITE FOR RESIDUE MG M 9219 source : CD1 37) chain M residue 224 type sequence E description BINDING SITE FOR RESIDUE MG M 9219 source : CD1 38) chain M residue 225 type sequence S description BINDING SITE FOR RESIDUE MG M 9219 source : CD1 39) chain M residue 228 type sequence A description BINDING SITE FOR RESIDUE MG M 9219 source : CD1 40) chain M residue 318 type sequence P description BINDING SITE FOR RESIDUE MG M 9220 source : CD2 41) chain M residue 1105 type sequence K description BINDING SITE FOR RESIDUE MG M 9225 source : CD5 42) chain M residue 1104 type sequence E description BINDING SITE FOR RESIDUE MG M 9227 source : CD6 43) chain M residue 1061 type sequence E description BINDING SITE FOR RESIDUE MG M 9230 source : CD7 44) chain M residue 706 type sequence E description BINDING SITE FOR RESIDUE MG M 9234 source : CD8 45) chain M residue 626 type sequence R description BINDING SITE FOR RESIDUE MG M 9239 source : DD1 46) chain M residue 637 type sequence L description BINDING SITE FOR RESIDUE MG M 9239 source : DD1 47) chain M residue 638 type sequence D description BINDING SITE FOR RESIDUE MG M 9239 source : DD1 48) chain M residue 639 type sequence Q description BINDING SITE FOR RESIDUE MG M 9239 source : DD1 49) chain M residue 1061 type sequence E description BINDING SITE FOR RESIDUE MG M 9241 source : DD2 50) chain M residue 1080 type sequence S description BINDING SITE FOR RESIDUE MG M 9241 source : DD2 51) chain M residue 368 type sequence T description BINDING SITE FOR RESIDUE MG M 9242 source : DD3 52) chain M residue 150 type sequence P description BINDING SITE FOR RESIDUE MG M 9247 source : DD4 53) chain M residue 151 type sequence D description BINDING SITE FOR RESIDUE MG M 9247 source : DD4 54) chain M residue 158 type sequence Y description BINDING SITE FOR RESIDUE MG M 9247 source : DD4 55) chain M residue 55 type sequence E description BINDING SITE FOR RESIDUE MG M 9248 source : DD5 56) chain M residue 57 type sequence E description BINDING SITE FOR RESIDUE MG M 9248 source : DD5 57) chain M residue 998 type sequence Y description BINDING SITE FOR RESIDUE MG M 9250 source : DD6 58) chain M residue 1000 type sequence M description BINDING SITE FOR RESIDUE MG M 9250 source : DD6 59) chain M residue 512 type sequence R description BINDING SITE FOR RESIDUE MG M 9256 source : DD7 60) chain M residue 461 type sequence V description BINDING SITE FOR RESIDUE MG M 9260 source : DD8 61) chain M residue 736 type sequence D description BINDING SITE FOR RESIDUE MG M 9261 source : DD9 62) chain M residue 1024 type sequence K description BINDING SITE FOR RESIDUE MG M 9263 source : ED1 63) chain M residue 1041 type sequence E description BINDING SITE FOR RESIDUE MG M 9268 source : ED2 64) chain M residue 247 type sequence P description BINDING SITE FOR RESIDUE MG M 9275 source : ED4 65) chain M residue 651 type sequence K description BINDING SITE FOR RESIDUE MG M 9295 source : ED5 66) chain M residue 652 type sequence G description BINDING SITE FOR RESIDUE MG M 9295 source : ED5 67) chain M residue 653 type sequence D description BINDING SITE FOR RESIDUE MG M 9295 source : ED5 68) chain M residue 836 type sequence G description BINDING SITE FOR RESIDUE MG M 9299 source : ED6 69) chain M residue 999 type sequence H description BINDING SITE FOR RESIDUE MG M 9299 source : ED6 70) chain M residue 492 type sequence D description BINDING SITE FOR RESIDUE MG M 9300 source : ED7 71) chain M residue 642 type sequence R description BINDING SITE FOR RESIDUE MG M 9310 source : ED8 72) chain M residue 644 type sequence V description BINDING SITE FOR RESIDUE MG M 9310 source : ED8 73) chain M residue 647 type sequence Q description BINDING SITE FOR RESIDUE MG M 9310 source : ED8 74) chain M residue 707 type sequence R description BINDING SITE FOR RESIDUE MG M 9312 source : ED9 75) chain M residue 695 type sequence L description BINDING SITE FOR RESIDUE MG M 9319 source : FD1 76) chain M residue 1106 type sequence D description BINDING SITE FOR RESIDUE MG M 9320 source : FD2 77) chain M residue 811 type sequence P description BINDING SITE FOR RESIDUE MG M 9321 source : FD3 78) chain M residue 976 type sequence D description BINDING SITE FOR RESIDUE MG M 9324 source : FD4 79) chain M residue 978 type sequence R description BINDING SITE FOR RESIDUE MG M 9324 source : FD4 80) chain M residue 979 type sequence T description BINDING SITE FOR RESIDUE MG M 9324 source : FD4 81) chain M residue 608 type sequence G description BINDING SITE FOR RESIDUE MG M 9400 source : FD5 82) chain M residue 639 type sequence Q description BINDING SITE FOR RESIDUE MG M 9400 source : FD5 83) chain M residue 706 type sequence E description BINDING SITE FOR RESIDUE MG M 9401 source : FD6 84) chain M residue 708 type sequence Y description BINDING SITE FOR RESIDUE MG M 9401 source : FD6 85) chain M residue 1004 type sequence K description BINDING SITE FOR RESIDUE MG M 9401 source : FD6 86) chain M residue 838 type sequence K description BINDING SITE FOR RESIDUE MG M 9407 source : FD7 87) chain M residue 57 type sequence E description BINDING SITE FOR RESIDUE MG M 9409 source : FD8 88) chain M residue 198 type sequence R description BINDING SITE FOR RESIDUE MG M 9411 source : FD9 89) chain M residue 228 type sequence A description BINDING SITE FOR RESIDUE MG M 9411 source : FD9 90) chain M residue 229 type sequence M description BINDING SITE FOR RESIDUE MG M 9411 source : FD9 91) chain M residue 230 type sequence R description BINDING SITE FOR RESIDUE MG M 9411 source : FD9 92) chain M residue 20 type sequence E description BINDING SITE FOR RESIDUE MG M 9416 source : GD2 93) chain M residue 205 type sequence E description BINDING SITE FOR RESIDUE MG M 9424 source : GD3 94) chain M residue 1104 type sequence E description BINDING SITE FOR RESIDUE MG M 9440 source : GD5 95) chain M residue 1105 type sequence K description BINDING SITE FOR RESIDUE MG M 9440 source : GD5 96) chain M residue 224 type sequence E description BINDING SITE FOR RESIDUE MG M 9442 source : GD7 97) chain M residue 365 type sequence D description BINDING SITE FOR RESIDUE MG M 9447 source : GD8 98) chain M residue 366 type sequence S description BINDING SITE FOR RESIDUE MG M 9447 source : GD8 99) chain M residue 1 type sequence M description BINDING SITE FOR RESIDUE MG M 9452 source : GD9 100) chain M residue 180 type sequence G description BINDING SITE FOR RESIDUE MG M 9471 source : HD1 101) chain M residue 49 type sequence R description BINDING SITE FOR RESIDUE MG M 9486 source : HD3 102) chain M residue 1097 type sequence L description BINDING SITE FOR RESIDUE MG N 9467 source : PD4 103) chain M residue 1072 type sequence K description BINDING SITE FOR RESIDUE MG P 9226 source : QD9

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