eF-site ID 2a69-L PDB Code 2a69 Chain L click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence L:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ Description Functional site 1) chain L residue 229 type sequence Q description BINDING SITE FOR RESIDUE MG K 9191 source : YC2 2) chain L residue 28 type sequence L description BINDING SITE FOR RESIDUE MG L 9182 source : ZC5 3) chain L residue 29 type sequence E description BINDING SITE FOR RESIDUE MG L 9182 source : ZC5 4) chain L residue 189 type sequence R description BINDING SITE FOR RESIDUE MG L 9182 source : ZC5 5) chain L residue 191 type sequence D description BINDING SITE FOR RESIDUE MG L 9182 source : ZC5 6) chain L residue 192 type sequence L description BINDING SITE FOR RESIDUE MG L 9182 source : ZC5 7) chain L residue 51 type sequence T description BINDING SITE FOR RESIDUE MG L 9183 source : ZC6 8) chain L residue 170 type sequence V description BINDING SITE FOR RESIDUE MG L 9183 source : ZC6 9) chain L residue 172 type sequence S description BINDING SITE FOR RESIDUE MG L 9183 source : ZC6 10) chain L residue 202 type sequence D description BINDING SITE FOR RESIDUE MG L 9183 source : ZC6 11) chain L residue 93 type sequence S description BINDING SITE FOR RESIDUE MG L 9218 source : ZC7 12) chain L residue 159 type sequence K description BINDING SITE FOR RESIDUE MG L 9245 source : ZC8 13) chain L residue 219 type sequence R description BINDING SITE FOR RESIDUE MG L 9246 source : ZC9 14) chain L residue 69 type sequence P description BINDING SITE FOR RESIDUE MG L 9252 source : AD1 15) chain L residue 135 type sequence G description BINDING SITE FOR RESIDUE MG L 9252 source : AD1 16) chain L residue 60 type sequence D description BINDING SITE FOR RESIDUE MG L 9278 source : AD2 17) chain L residue 13 type sequence V description BINDING SITE FOR RESIDUE MG L 9289 source : AD3 18) chain L residue 14 type sequence R description BINDING SITE FOR RESIDUE MG L 9289 source : AD3 19) chain L residue 133 type sequence E description BINDING SITE FOR RESIDUE MG L 9306 source : AD4 20) chain L residue 59 type sequence E description BINDING SITE FOR RESIDUE MG L 9307 source : AD5 21) chain L residue 62 type sequence L description BINDING SITE FOR RESIDUE MG L 9309 source : AD6 22) chain L residue 118 type sequence A description BINDING SITE FOR RESIDUE MG L 9314 source : AD7 23) chain L residue 119 type sequence D description BINDING SITE FOR RESIDUE MG L 9314 source : AD7 24) chain L residue 93 type sequence S description BINDING SITE FOR RESIDUE MG L 9437 source : AD8 25) chain L residue 77 type sequence E description BINDING SITE FOR RESIDUE MG N 9465 source : PD3

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