eF-site ID 2a69-F PDB Code 2a69 Chain F click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence F:  KISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAI KKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDP KTVEEIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLR LVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRF KFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSR TARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQE PVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEE LEKALSKLSEREAMVLKLRKGLIDGEEVGAFFGVTRERIR QIENKALRKLKYHESRTRKLRDFLD Description Functional site 1) chain F residue 323 type sequence D description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 2) chain F residue 340 type sequence S description BINDING SITE FOR RESIDUE MG C 9176 source : JC9 3) chain F residue 342 type sequence V description BINDING SITE FOR RESIDUE MG C 9176 source : JC9 4) chain F residue 373 type sequence K description BINDING SITE FOR RESIDUE MG C 9178 source : KC1 5) chain F residue 374 type sequence G description BINDING SITE FOR RESIDUE MG C 9178 source : KC1 6) chain F residue 326 type sequence D description BINDING SITE FOR RESIDUE MG D 9023 source : MC2 7) chain F residue 129 type sequence E description BINDING SITE FOR RESIDUE MG D 9333 source : SC7 8) chain F residue 132 type sequence R description BINDING SITE FOR RESIDUE MG D 9333 source : SC7 9) chain F residue 415 type sequence T description BINDING SITE FOR RESIDUE MG F 9008 source : VC6 10) chain F residue 416 type sequence R description BINDING SITE FOR RESIDUE MG F 9008 source : VC6 11) chain F residue 206 type sequence G description BINDING SITE FOR RESIDUE MG F 9035 source : VC7 12) chain F residue 207 type sequence L description BINDING SITE FOR RESIDUE MG F 9035 source : VC7 13) chain F residue 371 type sequence L description BINDING SITE FOR RESIDUE MG F 9048 source : VC8 14) chain F residue 372 type sequence R description BINDING SITE FOR RESIDUE MG F 9048 source : VC8 15) chain F residue 254 type sequence Q description BINDING SITE FOR RESIDUE MG F 9057 source : VC9 16) chain F residue 395 type sequence E description BINDING SITE FOR RESIDUE MG F 9060 source : WC1 17) chain F residue 256 type sequence R description BINDING SITE FOR RESIDUE MG F 9098 source : WC2 18) chain F residue 359 type sequence S description BINDING SITE FOR RESIDUE MG F 9109 source : WC4 19) chain F residue 360 type sequence K description BINDING SITE FOR RESIDUE MG F 9109 source : WC4 20) chain F residue 361 type sequence L description BINDING SITE FOR RESIDUE MG F 9109 source : WC4 21) chain F residue 289 type sequence E description BINDING SITE FOR RESIDUE MG F 9123 source : WC5 22) chain F residue 372 type sequence R description BINDING SITE FOR RESIDUE MG F 9139 source : WC6 23) chain F residue 263 type sequence H description BINDING SITE FOR RESIDUE MG F 9148 source : WC7 24) chain F residue 384 type sequence E description BINDING SITE FOR RESIDUE MG F 9157 source : WC8 25) chain F residue 361 type sequence L description BINDING SITE FOR RESIDUE MG F 9159 source : WC9 26) chain F residue 362 type sequence S description BINDING SITE FOR RESIDUE MG F 9159 source : WC9 27) chain F residue 363 type sequence E description BINDING SITE FOR RESIDUE MG F 9159 source : WC9 28) chain F residue 147 type sequence L description BINDING SITE FOR RESIDUE MG F 9172 source : XC1 29) chain F residue 134 type sequence K description BINDING SITE FOR RESIDUE MG F 9356 source : XC2 30) chain F residue 74 type sequence K description BINDING SITE FOR RESIDUE MG F 9370 source : XC3 31) chain F residue 364 type sequence R description BINDING SITE FOR RESIDUE MG F 9387 source : XC6 32) chain F residue 269 type sequence N description BINDING SITE FOR RESIDUE MG F 9390 source : XC7 33) chain F residue 273 type sequence R description BINDING SITE FOR RESIDUE MG F 9390 source : XC7 34) chain F residue 276 type sequence R description BINDING SITE FOR RESIDUE MG F 9390 source : XC7 35) chain F residue 357 type sequence A description BINDING SITE FOR RESIDUE MG F 9393 source : XC8 36) chain F residue 360 type sequence K description BINDING SITE FOR RESIDUE MG F 9393 source : XC8 37) chain F residue 361 type sequence L description BINDING SITE FOR RESIDUE MG F 9393 source : XC8 38) chain F residue 187-194 type prosite sequence LIEANLRL description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL source prosite : PS00867

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