eF-site ID 2a69-D PDB Code 2a69 Chain D click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence D:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA Description Functional site 1) chain D residue 872 type sequence R description BINDING SITE FOR RESIDUE MG B 9093 source : DC5 2) chain D residue 651 type sequence E description BINDING SITE FOR RESIDUE MG C 9003 source : EC8 3) chain D residue 9 type sequence R description BINDING SITE FOR RESIDUE MG C 9004 source : EC9 4) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D 7058 source : LC1 5) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D 7058 source : LC1 6) chain D residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN D 7058 source : LC1 7) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D 7058 source : LC1 8) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 7112 source : LC2 9) chain D residue 1189 type sequence R description BINDING SITE FOR RESIDUE ZN D 7112 source : LC2 10) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 7112 source : LC2 11) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 7112 source : LC2 12) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 7112 source : LC2 13) chain D residue 23 type sequence Y description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 14) chain D residue 24 type sequence G description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 15) chain D residue 25 type sequence E description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 16) chain D residue 26 type sequence V description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 17) chain D residue 49 type sequence I description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 18) chain D residue 91 type sequence G description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 19) chain D residue 92 type sequence H description BINDING SITE FOR RESIDUE MG D 9001 source : LC3 20) chain D residue 1078 type sequence R description BINDING SITE FOR RESIDUE MG D 9005 source : LC4 21) chain D residue 471 type sequence E description BINDING SITE FOR RESIDUE MG D 9006 source : LC5 22) chain D residue 472 type sequence A description BINDING SITE FOR RESIDUE MG D 9006 source : LC5 23) chain D residue 475 type sequence K description BINDING SITE FOR RESIDUE MG D 9006 source : LC5 24) chain D residue 1101 type sequence V description BINDING SITE FOR RESIDUE MG D 9009 source : LC6 25) chain D residue 1378 type sequence Y description BINDING SITE FOR RESIDUE MG D 9009 source : LC6 26) chain D residue 1427 type sequence S description BINDING SITE FOR RESIDUE MG D 9009 source : LC6 27) chain D residue 1428 type sequence A description BINDING SITE FOR RESIDUE MG D 9009 source : LC6 28) chain D residue 1431 type sequence T description BINDING SITE FOR RESIDUE MG D 9009 source : LC6 29) chain D residue 900 type sequence I description BINDING SITE FOR RESIDUE MG D 9014 source : LC8 30) chain D residue 901 type sequence Q description BINDING SITE FOR RESIDUE MG D 9014 source : LC8 31) chain D residue 902 type sequence L description BINDING SITE FOR RESIDUE MG D 9014 source : LC8 32) chain D residue 1468 type sequence L description BINDING SITE FOR RESIDUE MG D 9017 source : LC9 33) chain D residue 1157 type sequence G description BINDING SITE FOR RESIDUE MG D 9018 source : MC1 34) chain D residue 1159 type sequence R description BINDING SITE FOR RESIDUE MG D 9018 source : MC1 35) chain D residue 610 type sequence K description BINDING SITE FOR RESIDUE MG D 9023 source : MC2 36) chain D residue 2 type sequence K description BINDING SITE FOR RESIDUE MG D 9024 source : MC3 37) chain D residue 3 type sequence K description BINDING SITE FOR RESIDUE MG D 9024 source : MC3 38) chain D residue 631 type sequence I description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 39) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 40) chain D residue 740 type sequence F description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 41) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 42) chain D residue 742 type sequence G description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 43) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D 9028 source : MC4 44) chain D residue 15 type sequence P description BINDING SITE FOR RESIDUE MG D 9029 source : MC5 45) chain D residue 16 type sequence E description BINDING SITE FOR RESIDUE MG D 9029 source : MC5 46) chain D residue 986 type sequence R description BINDING SITE FOR RESIDUE MG D 9030 source : MC6 47) chain D residue 989 type sequence Y description BINDING SITE FOR RESIDUE MG D 9030 source : MC6 48) chain D residue 107 type sequence D description BINDING SITE FOR RESIDUE MG D 9034 source : MC7 49) chain D residue 1442 type sequence N description BINDING SITE FOR RESIDUE MG D 9034 source : MC7 50) chain D residue 1445 type sequence H description BINDING SITE FOR RESIDUE MG D 9034 source : MC7 51) chain D residue 806 type sequence F description BINDING SITE FOR RESIDUE MG D 9036 source : MC8 52) chain D residue 807 type sequence A description BINDING SITE FOR RESIDUE MG D 9036 source : MC8 53) chain D residue 831 type sequence G description BINDING SITE FOR RESIDUE MG D 9036 source : MC8 54) chain D residue 832 type sequence R description BINDING SITE FOR RESIDUE MG D 9036 source : MC8 55) chain D residue 833 type sequence E description BINDING SITE FOR RESIDUE MG D 9036 source : MC8 56) chain D residue 1205 type sequence Y description BINDING SITE FOR RESIDUE MG D 9038 source : MC9 57) chain D residue 1208 type sequence D description BINDING SITE FOR RESIDUE MG D 9038 source : MC9 58) chain D residue 1219 type sequence E description BINDING SITE FOR RESIDUE MG D 9038 source : MC9 59) chain D residue 1224 type sequence V description BINDING SITE FOR RESIDUE MG D 9038 source : MC9 60) chain D residue 371 type sequence I description BINDING SITE FOR RESIDUE MG D 9052 source : NC3 61) chain D residue 372 type sequence D description BINDING SITE FOR RESIDUE MG D 9052 source : NC3 62) chain D residue 373 type sequence P description BINDING SITE FOR RESIDUE MG D 9052 source : NC3 63) chain D residue 1109 type sequence E description BINDING SITE FOR RESIDUE MG D 9054 source : NC4 64) chain D residue 1110 type sequence A description BINDING SITE FOR RESIDUE MG D 9054 source : NC4 65) chain D residue 1196 type sequence T description BINDING SITE FOR RESIDUE MG D 9054 source : NC4 66) chain D residue 1128 type sequence V description BINDING SITE FOR RESIDUE MG D 9058 source : NC5 67) chain D residue 1129 type sequence T description BINDING SITE FOR RESIDUE MG D 9058 source : NC5 68) chain D residue 1130 type sequence R description BINDING SITE FOR RESIDUE MG D 9058 source : NC5 69) chain D residue 1131 type sequence S description BINDING SITE FOR RESIDUE MG D 9058 source : NC5 70) chain D residue 826 type sequence P description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 71) chain D residue 827 type sequence I description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 72) chain D residue 828 type sequence K description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 73) chain D residue 829 type sequence V description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 74) chain D residue 835 type sequence S description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 75) chain D residue 836 type sequence V description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 76) chain D residue 837 type sequence G description BINDING SITE FOR RESIDUE MG D 9062 source : NC6 77) chain D residue 1241 type sequence F description BINDING SITE FOR RESIDUE MG D 9063 source : NC7 78) chain D residue 807 type sequence A description BINDING SITE FOR RESIDUE MG D 9064 source : NC8 79) chain D residue 833 type sequence E description BINDING SITE FOR RESIDUE MG D 9064 source : NC8 80) chain D residue 1121 type sequence P description BINDING SITE FOR RESIDUE MG D 9070 source : OC1 81) chain D residue 1184 type sequence Q description BINDING SITE FOR RESIDUE MG D 9070 source : OC1 82) chain D residue 1185 type sequence E description BINDING SITE FOR RESIDUE MG D 9070 source : OC1 83) chain D residue 1239 type sequence R description BINDING SITE FOR RESIDUE MG D 9072 source : OC2 84) chain D residue 1173 type sequence L description BINDING SITE FOR RESIDUE MG D 9073 source : OC3 85) chain D residue 1176 type sequence K description BINDING SITE FOR RESIDUE MG D 9073 source : OC3 86) chain D residue 1251 type sequence D description BINDING SITE FOR RESIDUE MG D 9077 source : OC4 87) chain D residue 1252 type sequence I description BINDING SITE FOR RESIDUE MG D 9077 source : OC4 88) chain D residue 546 type sequence R description BINDING SITE FOR RESIDUE MG D 9084 source : OC5 89) chain D residue 227 type sequence L description BINDING SITE FOR RESIDUE MG D 9087 source : OC7 90) chain D residue 172 type sequence P description BINDING SITE FOR RESIDUE MG D 9089 source : OC8 91) chain D residue 389 type sequence E description BINDING SITE FOR RESIDUE MG D 9089 source : OC8 92) chain D residue 390 type sequence P description BINDING SITE FOR RESIDUE MG D 9089 source : OC8 93) chain D residue 772 type sequence P description BINDING SITE FOR RESIDUE MG D 9095 source : PC1 94) chain D residue 1208 type sequence D description BINDING SITE FOR RESIDUE MG D 9095 source : PC1 95) chain D residue 1367 type sequence H description BINDING SITE FOR RESIDUE MG D 9095 source : PC1 96) chain D residue 800 type sequence K description BINDING SITE FOR RESIDUE MG D 9102 source : PC4 97) chain D residue 1009 type sequence K description BINDING SITE FOR RESIDUE MG D 9113 source : PC6 98) chain D residue 1010 type sequence N description BINDING SITE FOR RESIDUE MG D 9113 source : PC6 99) chain D residue 534 type sequence R description BINDING SITE FOR RESIDUE MG D 9117 source : PC7 100) chain D residue 1376 type sequence M description BINDING SITE FOR RESIDUE MG D 9118 source : PC8 101) chain D residue 727 type sequence Q description BINDING SITE FOR RESIDUE MG D 9120 source : PC9 102) chain D residue 529 type sequence Q description BINDING SITE FOR RESIDUE MG D 9121 source : QC1 103) chain D residue 530 type sequence V description BINDING SITE FOR RESIDUE MG D 9121 source : QC1 104) chain D residue 387 type sequence L description BINDING SITE FOR RESIDUE MG D 9127 source : QC2 105) chain D residue 72 type sequence V description BINDING SITE FOR RESIDUE MG D 9130 source : QC3 106) chain D residue 1012 type sequence E description BINDING SITE FOR RESIDUE MG D 9133 source : QC5 107) chain D residue 1013 type sequence E description BINDING SITE FOR RESIDUE MG D 9133 source : QC5 108) chain D residue 832 type sequence R description BINDING SITE FOR RESIDUE MG D 9135 source : QC6 109) chain D residue 1304 type sequence K description BINDING SITE FOR RESIDUE MG D 9137 source : QC7 110) chain D residue 469 type sequence D description BINDING SITE FOR RESIDUE MG D 9141 source : QC9 111) chain D residue 879 type sequence R description BINDING SITE FOR RESIDUE MG D 9146 source : RC1 112) chain D residue 903 type sequence D description BINDING SITE FOR RESIDUE MG D 9146 source : RC1 113) chain D residue 1161 type sequence E description BINDING SITE FOR RESIDUE MG D 9147 source : RC2 114) chain D residue 74 type sequence E description BINDING SITE FOR RESIDUE MG D 9152 source : RC4 115) chain D residue 654 type sequence K description BINDING SITE FOR RESIDUE MG D 9158 source : RC5 116) chain D residue 1314 type sequence K description BINDING SITE FOR RESIDUE MG D 9163 source : RC7 117) chain D residue 1182 type sequence E description BINDING SITE FOR RESIDUE MG D 9165 source : RC8 118) chain D residue 872 type sequence R description BINDING SITE FOR RESIDUE MG D 9166 source : RC9 119) chain D residue 1180 type sequence A description BINDING SITE FOR RESIDUE MG D 9174 source : SC2 120) chain D residue 183 type sequence E description BINDING SITE FOR RESIDUE MG D 9328 source : SC3 121) chain D residue 216 type sequence V description BINDING SITE FOR RESIDUE MG D 9328 source : SC3 122) chain D residue 220 type sequence R description BINDING SITE FOR RESIDUE MG D 9328 source : SC3 123) chain D residue 221 type sequence A description BINDING SITE FOR RESIDUE MG D 9328 source : SC3 124) chain D residue 1405 type sequence E description BINDING SITE FOR RESIDUE MG D 9329 source : SC4 125) chain D residue 1406 type sequence R description BINDING SITE FOR RESIDUE MG D 9329 source : SC4 126) chain D residue 1409 type sequence A description BINDING SITE FOR RESIDUE MG D 9329 source : SC4 127) chain D residue 1410 type sequence E description BINDING SITE FOR RESIDUE MG D 9329 source : SC4 128) chain D residue 1411 type sequence G description BINDING SITE FOR RESIDUE MG D 9329 source : SC4 129) chain D residue 1017 type sequence F description BINDING SITE FOR RESIDUE MG D 9330 source : SC5 130) chain D residue 1018 type sequence N description BINDING SITE FOR RESIDUE MG D 9330 source : SC5 131) chain D residue 1019 type sequence P description BINDING SITE FOR RESIDUE MG D 9330 source : SC5 132) chain D residue 558 type sequence L description BINDING SITE FOR RESIDUE MG D 9333 source : SC7 133) chain D residue 559 type sequence A description BINDING SITE FOR RESIDUE MG D 9333 source : SC7 134) chain D residue 898 type sequence E description BINDING SITE FOR RESIDUE MG D 9338 source : TC3 135) chain D residue 250 type sequence L description BINDING SITE FOR RESIDUE MG D 9339 source : TC4 136) chain D residue 251 type sequence F description BINDING SITE FOR RESIDUE MG D 9339 source : TC4 137) chain D residue 542 type sequence D description BINDING SITE FOR RESIDUE MG D 9341 source : TC5 138) chain D residue 592 type sequence T description BINDING SITE FOR RESIDUE MG D 9341 source : TC5 139) chain D residue 593 type sequence N description BINDING SITE FOR RESIDUE MG D 9341 source : TC5 140) chain D residue 1185 type sequence E description BINDING SITE FOR RESIDUE MG D 9347 source : TC7 141) chain D residue 744 type sequence Q description BINDING SITE FOR RESIDUE MG D 9349 source : TC8 142) chain D residue 1126 type sequence D description BINDING SITE FOR RESIDUE MG D 9351 source : TC9 143) chain D residue 1129 type sequence T description BINDING SITE FOR RESIDUE MG D 9351 source : TC9 144) chain D residue 1130 type sequence R description BINDING SITE FOR RESIDUE MG D 9351 source : TC9 145) chain D residue 1166 type sequence L description BINDING SITE FOR RESIDUE MG D 9367 source : UC1 146) chain D residue 1167 type sequence S description BINDING SITE FOR RESIDUE MG D 9367 source : UC1 147) chain D residue 1170 type sequence D description BINDING SITE FOR RESIDUE MG D 9367 source : UC1 148) chain D residue 1171 type sequence V description BINDING SITE FOR RESIDUE MG D 9367 source : UC1 149) chain D residue 1133 type sequence R description BINDING SITE FOR RESIDUE MG D 9373 source : UC3 150) chain D residue 1248 type sequence G description BINDING SITE FOR RESIDUE MG D 9374 source : UC4 151) chain D residue 1249 type sequence A description BINDING SITE FOR RESIDUE MG D 9374 source : UC4 152) chain D residue 1429 type sequence L description BINDING SITE FOR RESIDUE MG D 9379 source : UC5 153) chain D residue 1430 type sequence S description BINDING SITE FOR RESIDUE MG D 9379 source : UC5 154) chain D residue 1441 type sequence Q description BINDING SITE FOR RESIDUE MG D 9379 source : UC5 155) chain D residue 646 type sequence K description BINDING SITE FOR RESIDUE MG D 9386 source : UC7 156) chain D residue 688 type sequence W description BINDING SITE FOR RESIDUE MG D 9386 source : UC7 157) chain D residue 1005 type sequence Q description BINDING SITE FOR RESIDUE MG D 9388 source : UC8 158) chain D residue 549 type sequence N description BINDING SITE FOR RESIDUE MG F 9057 source : VC9 159) chain D residue 404 type sequence E description BINDING SITE FOR RESIDUE MG K 9301 source : ZC1 160) chain D residue 414 type sequence R description BINDING SITE FOR RESIDUE MG K 9301 source : ZC1 161) chain D residue 1310 type sequence R description BINDING SITE FOR RESIDUE MG P 9315 source : RD8 162) chain D residue 1327 type sequence R description BINDING SITE FOR RESIDUE MG P 9315 source : RD8 163) chain D residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 164) chain D residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 165) chain D residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 166) chain D residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 167) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 168) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 169) chain D residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 170) chain D residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 171) chain D residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 172) chain D residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 173) chain D residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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