eF-site ID 2a69-C PDB Code 2a69 Chain C click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR Description Functional site 1) chain C residue 696 type sequence K description BINDING SITE FOR RESIDUE MG A 9081 source : BC2 2) chain C residue 698 type sequence D description BINDING SITE FOR RESIDUE MG A 9081 source : BC2 3) chain C residue 696 type sequence K description BINDING SITE FOR RESIDUE MG A 9088 source : BC3 4) chain C residue 693 type sequence E description BINDING SITE FOR RESIDUE MG A 9156 source : BC7 5) chain C residue 134 type sequence R description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 6) chain C residue 390 type sequence Q description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 7) chain C residue 392 type sequence S description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 8) chain C residue 393 type sequence Q description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 9) chain C residue 394 type sequence F description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 10) chain C residue 396 type sequence D description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 11) chain C residue 406 type sequence H description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 12) chain C residue 409 type sequence R description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 13) chain C residue 411 type sequence S description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 14) chain C residue 413 type sequence L description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 15) chain C residue 444 type sequence P description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 16) chain C residue 452 type sequence I description BINDING SITE FOR RESIDUE RPT C 8001 source : EC7 17) chain C residue 1026 type sequence Q description BINDING SITE FOR RESIDUE MG C 9003 source : EC8 18) chain C residue 1027 type sequence F description BINDING SITE FOR RESIDUE MG C 9003 source : EC8 19) chain C residue 1098 type sequence D description BINDING SITE FOR RESIDUE MG C 9004 source : EC9 20) chain C residue 1099 type sequence V description BINDING SITE FOR RESIDUE MG C 9004 source : EC9 21) chain C residue 1100 type sequence Q description BINDING SITE FOR RESIDUE MG C 9004 source : EC9 22) chain C residue 290 type sequence L description BINDING SITE FOR RESIDUE MG C 9015 source : FC1 23) chain C residue 299 type sequence K description BINDING SITE FOR RESIDUE MG C 9015 source : FC1 24) chain C residue 300 type sequence D description BINDING SITE FOR RESIDUE MG C 9015 source : FC1 25) chain C residue 301 type sequence E description BINDING SITE FOR RESIDUE MG C 9015 source : FC1 26) chain C residue 302 type sequence V description BINDING SITE FOR RESIDUE MG C 9015 source : FC1 27) chain C residue 210 type sequence E description BINDING SITE FOR RESIDUE MG C 9019 source : FC2 28) chain C residue 1000 type sequence M description BINDING SITE FOR RESIDUE MG C 9020 source : FC3 29) chain C residue 447 type sequence A description BINDING SITE FOR RESIDUE MG C 9021 source : FC4 30) chain C residue 573 type sequence R description BINDING SITE FOR RESIDUE MG C 9022 source : FC5 31) chain C residue 698 type sequence D description BINDING SITE FOR RESIDUE MG C 9022 source : FC5 32) chain C residue 826 type sequence Y description BINDING SITE FOR RESIDUE MG C 9025 source : FC6 33) chain C residue 748 type sequence E description BINDING SITE FOR RESIDUE MG C 9031 source : FC8 34) chain C residue 797 type sequence G description BINDING SITE FOR RESIDUE MG C 9031 source : FC8 35) chain C residue 798 type sequence G description BINDING SITE FOR RESIDUE MG C 9031 source : FC8 36) chain C residue 463 type sequence E description BINDING SITE FOR RESIDUE MG C 9042 source : GC1 37) chain C residue 717 type sequence L description BINDING SITE FOR RESIDUE MG C 9046 source : GC2 38) chain C residue 761 type sequence F description BINDING SITE FOR RESIDUE MG C 9046 source : GC2 39) chain C residue 763 type sequence G description BINDING SITE FOR RESIDUE MG C 9046 source : GC2 40) chain C residue 422 type sequence R description BINDING SITE FOR RESIDUE MG C 9047 source : GC3 41) chain C residue 551 type sequence E description BINDING SITE FOR RESIDUE MG C 9049 source : GC4 42) chain C residue 906 type sequence F description BINDING SITE FOR RESIDUE MG C 9049 source : GC4 43) chain C residue 910 type sequence K description BINDING SITE FOR RESIDUE MG C 9049 source : GC4 44) chain C residue 182 type sequence V description BINDING SITE FOR RESIDUE MG C 9050 source : GC5 45) chain C residue 220 type sequence G description BINDING SITE FOR RESIDUE MG C 9050 source : GC5 46) chain C residue 435 type sequence Y description BINDING SITE FOR RESIDUE MG C 9051 source : GC6 47) chain C residue 471 type sequence Y description BINDING SITE FOR RESIDUE MG C 9051 source : GC6 48) chain C residue 169 type sequence G description BINDING SITE FOR RESIDUE MG C 9053 source : GC7 49) chain C residue 170 type sequence P description BINDING SITE FOR RESIDUE MG C 9053 source : GC7 50) chain C residue 171 type sequence W description BINDING SITE FOR RESIDUE MG C 9053 source : GC7 51) chain C residue 1068 type sequence E description BINDING SITE FOR RESIDUE MG C 9055 source : GC8 52) chain C residue 546 type sequence L description BINDING SITE FOR RESIDUE MG C 9061 source : GC9 53) chain C residue 565 type sequence Q description BINDING SITE FOR RESIDUE MG C 9061 source : GC9 54) chain C residue 842 type sequence R description BINDING SITE FOR RESIDUE MG C 9061 source : GC9 55) chain C residue 602 type sequence E description BINDING SITE FOR RESIDUE MG C 9067 source : HC2 56) chain C residue 815 type sequence L description BINDING SITE FOR RESIDUE MG C 9076 source : HC4 57) chain C residue 573 type sequence R description BINDING SITE FOR RESIDUE MG C 9086 source : HC6 58) chain C residue 781 type sequence K description BINDING SITE FOR RESIDUE MG C 9090 source : HC7 59) chain C residue 108 type sequence I description BINDING SITE FOR RESIDUE MG C 9092 source : HC8 60) chain C residue 365 type sequence D description BINDING SITE FOR RESIDUE MG C 9092 source : HC8 61) chain C residue 366 type sequence S description BINDING SITE FOR RESIDUE MG C 9092 source : HC8 62) chain C residue 367 type sequence L description BINDING SITE FOR RESIDUE MG C 9092 source : HC8 63) chain C residue 368 type sequence T description BINDING SITE FOR RESIDUE MG C 9092 source : HC8 64) chain C residue 11 type sequence E description BINDING SITE FOR RESIDUE MG C 9107 source : HC9 65) chain C residue 12 type sequence V description BINDING SITE FOR RESIDUE MG C 9107 source : HC9 66) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE MG C 9107 source : HC9 67) chain C residue 14 type sequence P description BINDING SITE FOR RESIDUE MG C 9107 source : HC9 68) chain C residue 80 type sequence Q description BINDING SITE FOR RESIDUE MG C 9112 source : IC1 69) chain C residue 609 type sequence N description BINDING SITE FOR RESIDUE MG C 9114 source : IC2 70) chain C residue 624 type sequence P description BINDING SITE FOR RESIDUE MG C 9114 source : IC2 71) chain C residue 625 type sequence L description BINDING SITE FOR RESIDUE MG C 9114 source : IC2 72) chain C residue 620 type sequence L description BINDING SITE FOR RESIDUE MG C 9115 source : IC3 73) chain C residue 11 type sequence E description BINDING SITE FOR RESIDUE MG C 9119 source : IC4 74) chain C residue 12 type sequence V description BINDING SITE FOR RESIDUE MG C 9119 source : IC4 75) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE MG C 9119 source : IC4 76) chain C residue 14 type sequence P description BINDING SITE FOR RESIDUE MG C 9119 source : IC4 77) chain C residue 585 type sequence E description BINDING SITE FOR RESIDUE MG C 9122 source : IC5 78) chain C residue 619 type sequence R description BINDING SITE FOR RESIDUE MG C 9128 source : IC6 79) chain C residue 567 type sequence Q description BINDING SITE FOR RESIDUE MG C 9138 source : IC7 80) chain C residue 846 type sequence K description BINDING SITE FOR RESIDUE MG C 9138 source : IC7 81) chain C residue 978 type sequence R description BINDING SITE FOR RESIDUE MG C 9143 source : IC9 82) chain C residue 814 type sequence E description BINDING SITE FOR RESIDUE MG C 9145 source : JC1 83) chain C residue 815 type sequence L description BINDING SITE FOR RESIDUE MG C 9145 source : JC1 84) chain C residue 787 type sequence D description BINDING SITE FOR RESIDUE MG C 9149 source : JC2 85) chain C residue 107 type sequence L description BINDING SITE FOR RESIDUE MG C 9154 source : JC3 86) chain C residue 109 type sequence K description BINDING SITE FOR RESIDUE MG C 9154 source : JC3 87) chain C residue 75 type sequence E description BINDING SITE FOR RESIDUE MG C 9164 source : JC4 88) chain C residue 422 type sequence R description BINDING SITE FOR RESIDUE MG C 9168 source : JC5 89) chain C residue 202 type sequence Y description BINDING SITE FOR RESIDUE MG C 9170 source : JC7 90) chain C residue 300 type sequence D description BINDING SITE FOR RESIDUE MG C 9170 source : JC7 91) chain C residue 301 type sequence E description BINDING SITE FOR RESIDUE MG C 9170 source : JC7 92) chain C residue 648 type sequence R description BINDING SITE FOR RESIDUE MG C 9175 source : JC8 93) chain C residue 1026 type sequence Q description BINDING SITE FOR RESIDUE MG C 9176 source : JC9 94) chain C residue 769 type sequence P description BINDING SITE FOR RESIDUE MG C 9178 source : KC1 95) chain C residue 770 type sequence E description BINDING SITE FOR RESIDUE MG C 9178 source : KC1 96) chain C residue 87 type sequence D description BINDING SITE FOR RESIDUE MG C 9360 source : KC3 97) chain C residue 707 type sequence R description BINDING SITE FOR RESIDUE MG C 9360 source : KC3 98) chain C residue 824 type sequence R description BINDING SITE FOR RESIDUE MG C 9360 source : KC3 99) chain C residue 1004 type sequence K description BINDING SITE FOR RESIDUE MG C 9377 source : KC5 100) chain C residue 764 type sequence E description BINDING SITE FOR RESIDUE MG C 9391 source : KC7 101) chain C residue 765 type sequence S description BINDING SITE FOR RESIDUE MG C 9391 source : KC7 102) chain C residue 440 type sequence P description BINDING SITE FOR RESIDUE MG D 9005 source : LC4 103) chain C residue 1081 type sequence V description BINDING SITE FOR RESIDUE MG D 9017 source : LC9 104) chain C residue 950 type sequence L description BINDING SITE FOR RESIDUE MG D 9330 source : SC5 105) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

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