eF-site ID 2a69-B PDB Code 2a69 Chain B click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence B:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ Description Functional site 1) chain B residue 20 type sequence Y description BINDING SITE FOR RESIDUE MG B 9032 source : CC7 2) chain B residue 21 type sequence G description BINDING SITE FOR RESIDUE MG B 9032 source : CC7 3) chain B residue 198 type sequence R description BINDING SITE FOR RESIDUE MG B 9032 source : CC7 4) chain B residue 199 type sequence I description BINDING SITE FOR RESIDUE MG B 9032 source : CC7 5) chain B residue 51 type sequence T description BINDING SITE FOR RESIDUE MG B 9033 source : CC8 6) chain B residue 172 type sequence S description BINDING SITE FOR RESIDUE MG B 9033 source : CC8 7) chain B residue 202 type sequence D description BINDING SITE FOR RESIDUE MG B 9033 source : CC8 8) chain B residue 112 type sequence R description BINDING SITE FOR RESIDUE MG B 9056 source : DC1 9) chain B residue 67 type sequence T description BINDING SITE FOR RESIDUE MG B 9059 source : DC2 10) chain B residue 68 type sequence I description BINDING SITE FOR RESIDUE MG B 9059 source : DC2 11) chain B residue 73 type sequence E description BINDING SITE FOR RESIDUE MG B 9059 source : DC2 12) chain B residue 74 type sequence D description BINDING SITE FOR RESIDUE MG B 9059 source : DC2 13) chain B residue 74 type sequence D description BINDING SITE FOR RESIDUE MG B 9093 source : DC5 14) chain B residue 18 type sequence R description BINDING SITE FOR RESIDUE MG B 9103 source : DC6 15) chain B residue 7 type sequence K description BINDING SITE FOR RESIDUE MG B 9104 source : DC7 16) chain B residue 220 type sequence E description BINDING SITE FOR RESIDUE MG B 9116 source : DC9 17) chain B residue 32 type sequence F description BINDING SITE FOR RESIDUE MG B 9131 source : EC1 18) chain B residue 135 type sequence G description BINDING SITE FOR RESIDUE MG B 9358 source : EC2 19) chain B residue 67 type sequence T description BINDING SITE FOR RESIDUE MG B 9359 source : EC3 20) chain B residue 182 type sequence E description BINDING SITE FOR RESIDUE MG B 9457 source : EC5 21) chain B residue 188 type sequence Q description BINDING SITE FOR RESIDUE MG B 9458 source : EC6 22) chain B residue 74 type sequence D description BINDING SITE FOR RESIDUE MG D 9166 source : RC9

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