eF-site ID 2a69-A PDB Code 2a69 Chain A click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence A:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ Description Functional site 1) chain A residue 51 type sequence T description BINDING SITE FOR RESIDUE MG A 9002 source : AC1 2) chain A residue 83 type sequence K description BINDING SITE FOR RESIDUE MG A 9002 source : AC1 3) chain A residue 170 type sequence V description BINDING SITE FOR RESIDUE MG A 9002 source : AC1 4) chain A residue 204 type sequence S description BINDING SITE FOR RESIDUE MG A 9010 source : AC2 5) chain A residue 154 type sequence E description BINDING SITE FOR RESIDUE MG A 9012 source : AC3 6) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE MG A 9012 source : AC3 7) chain A residue 156 type sequence H description BINDING SITE FOR RESIDUE MG A 9012 source : AC3 8) chain A residue 157 type sequence G description BINDING SITE FOR RESIDUE MG A 9012 source : AC3 9) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE MG A 9013 source : AC4 10) chain A residue 29 type sequence E description BINDING SITE FOR RESIDUE MG A 9013 source : AC4 11) chain A residue 191 type sequence D description BINDING SITE FOR RESIDUE MG A 9013 source : AC4 12) chain A residue 192 type sequence L description BINDING SITE FOR RESIDUE MG A 9013 source : AC4 13) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE MG A 9027 source : AC6 14) chain A residue 112 type sequence R description BINDING SITE FOR RESIDUE MG A 9027 source : AC6 15) chain A residue 114 type sequence F description BINDING SITE FOR RESIDUE MG A 9027 source : AC6 16) chain A residue 59 type sequence E description BINDING SITE FOR RESIDUE MG A 9043 source : AC7 17) chain A residue 170 type sequence V description BINDING SITE FOR RESIDUE MG A 9068 source : AC8 18) chain A residue 162 type sequence I description BINDING SITE FOR RESIDUE MG A 9075 source : AC9 19) chain A residue 91 type sequence N description BINDING SITE FOR RESIDUE MG A 9078 source : BC1 20) chain A residue 83 type sequence K description BINDING SITE FOR RESIDUE MG A 9081 source : BC2 21) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE MG A 9081 source : BC2 22) chain A residue 45 type sequence L description BINDING SITE FOR RESIDUE MG A 9088 source : BC3 23) chain A residue 172 type sequence S description BINDING SITE FOR RESIDUE MG A 9088 source : BC3 24) chain A residue 93 type sequence S description BINDING SITE FOR RESIDUE MG A 9106 source : BC4 25) chain A residue 94 type sequence L description BINDING SITE FOR RESIDUE MG A 9106 source : BC4 26) chain A residue 119 type sequence D description BINDING SITE FOR RESIDUE MG A 9106 source : BC4 27) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE MG A 9111 source : BC5 28) chain A residue 29 type sequence E description BINDING SITE FOR RESIDUE MG A 9111 source : BC5 29) chain A residue 16 type sequence Q description BINDING SITE FOR RESIDUE MG A 9125 source : BC6 30) chain A residue 175 type sequence R description BINDING SITE FOR RESIDUE MG A 9156 source : BC7 31) chain A residue 102 type sequence K description BINDING SITE FOR RESIDUE MG A 9342 source : BC9 32) chain A residue 223 type sequence T description BINDING SITE FOR RESIDUE MG A 9345 source : CC1 33) chain A residue 134 type sequence E description BINDING SITE FOR RESIDUE MG A 9352 source : CC2 34) chain A residue 7 type sequence K description BINDING SITE FOR RESIDUE MG A 9354 source : CC3 35) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE MG A 9354 source : CC3 36) chain A residue 229 type sequence Q description BINDING SITE FOR RESIDUE MG B 9040 source : CC9 37) chain A residue 47 type sequence S description BINDING SITE FOR RESIDUE MG B 9131 source : EC1

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