eF-site ID 2a68-N
PDB Code 2a68
Chain N

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Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin
Classification TRANSFERASE
Compound DNA-directed RNA polymerase alpha chain
Source ORGANISM_SCIENTIFIC: Thermus thermophilus;
Sequence N:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER
DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT
KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT
ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL
RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG
VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI
LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI
LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG
RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL
EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI
LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR
LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN
PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV
GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA
RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI
QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS
FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT
QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE
TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL
ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD
LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD
AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL
QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ
QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS
SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG
TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV
EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT
CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG
TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV
ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV
KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ
KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ
VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS
WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP
AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA
Description


Functional site

1) chain N
residue 414
type
sequence R
description BINDING SITE FOR RESIDUE MG A 9145
source : BC5

2) chain N
residue 75
type
sequence R
description BINDING SITE FOR RESIDUE MG D 9094
source : RC1

3) chain N
residue 1311
type
sequence L
description BINDING SITE FOR RESIDUE MG F 9465
source : BD2

4) chain N
residue 9
type
sequence R
description BINDING SITE FOR RESIDUE MG M 9364
source : JD2

5) chain N
residue 58
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7059
source : LD2

6) chain N
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7059
source : LD2

7) chain N
residue 73
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7059
source : LD2

8) chain N
residue 76
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7059
source : LD2

9) chain N
residue 1112
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7113
source : LD3

10) chain N
residue 1194
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7113
source : LD3

11) chain N
residue 1201
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7113
source : LD3

12) chain N
residue 1204
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 7113
source : LD3

13) chain N
residue 706
type
sequence P
description BINDING SITE FOR RESIDUE MG N 9207
source : LD4

14) chain N
residue 707
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9207
source : LD4

15) chain N
residue 708
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9207
source : LD4

16) chain N
residue 712
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9207
source : LD4

17) chain N
residue 1438
type
sequence A
description BINDING SITE FOR RESIDUE MG N 9208
source : LD5

18) chain N
residue 1439
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9208
source : LD5

19) chain N
residue 1440
type
sequence F
description BINDING SITE FOR RESIDUE MG N 9208
source : LD5

20) chain N
residue 1443
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9208
source : LD5

21) chain N
residue 164
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9215
source : LD6

22) chain N
residue 165
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9215
source : LD6

23) chain N
residue 447
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9215
source : LD6

24) chain N
residue 448
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9215
source : LD6

25) chain N
residue 449
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9215
source : LD6

26) chain N
residue 884
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9218
source : LD7

27) chain N
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9221
source : LD8

28) chain N
residue 213
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9221
source : LD8

29) chain N
residue 1183
type
sequence I
description BINDING SITE FOR RESIDUE MG N 9225
source : LD9

30) chain N
residue 804
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9226
source : MD1

31) chain N
residue 830
type
sequence A
description BINDING SITE FOR RESIDUE MG N 9226
source : MD1

32) chain N
residue 831
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9226
source : MD1

33) chain N
residue 191
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9228
source : MD2

34) chain N
residue 195
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9228
source : MD2

35) chain N
residue 220
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9230
source : MD3

36) chain N
residue 369
type
sequence A
description BINDING SITE FOR RESIDUE MG N 9230
source : MD3

37) chain N
residue 656
type
sequence F
description BINDING SITE FOR RESIDUE MG N 9232
source : MD4

38) chain N
residue 694
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9232
source : MD4

39) chain N
residue 698
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9232
source : MD4

40) chain N
residue 188
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9238
source : MD5

41) chain N
residue 441
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9238
source : MD5

42) chain N
residue 952
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9242
source : MD6

43) chain N
residue 954
type
sequence A
description BINDING SITE FOR RESIDUE MG N 9242
source : MD6

44) chain N
residue 955
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9242
source : MD6

45) chain N
residue 956
type
sequence I
description BINDING SITE FOR RESIDUE MG N 9242
source : MD6

46) chain N
residue 901
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9244
source : MD7

47) chain N
residue 902
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9244
source : MD7

48) chain N
residue 903
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9244
source : MD7

49) chain N
residue 1030
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9245
source : MD8

50) chain N
residue 1031
type
sequence N
description BINDING SITE FOR RESIDUE MG N 9245
source : MD8

51) chain N
residue 1034
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9245
source : MD8

52) chain N
residue 1410
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9246
source : MD9

53) chain N
residue 1411
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9246
source : MD9

54) chain N
residue 1088
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9247
source : ND1

55) chain N
residue 1089
type
sequence A
description BINDING SITE FOR RESIDUE MG N 9247
source : ND1

56) chain N
residue 1410
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9248
source : ND2

57) chain N
residue 1411
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9248
source : ND2

58) chain N
residue 1412
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9248
source : ND2

59) chain N
residue 428
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9253
source : ND4

60) chain N
residue 429
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9253
source : ND4

61) chain N
residue 450
type
sequence Y
description BINDING SITE FOR RESIDUE MG N 9253
source : ND4

62) chain N
residue 138
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9256
source : ND5

63) chain N
residue 510
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9262
source : ND6

64) chain N
residue 387
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9263
source : ND7

65) chain N
residue 388
type
sequence H
description BINDING SITE FOR RESIDUE MG N 9263
source : ND7

66) chain N
residue 389
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9263
source : ND7

67) chain N
residue 1031
type
sequence N
description BINDING SITE FOR RESIDUE MG N 9266
source : ND8

68) chain N
residue 1033
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9266
source : ND8

69) chain N
residue 1034
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9266
source : ND8

70) chain N
residue 1037
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9266
source : ND8

71) chain N
residue 1235
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9273
source : ND9

72) chain N
residue 546
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9277
source : OD1

73) chain N
residue 593
type
sequence N
description BINDING SITE FOR RESIDUE MG N 9277
source : OD1

74) chain N
residue 1000
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9280
source : OD2

75) chain N
residue 1043
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9280
source : OD2

76) chain N
residue 401
type
sequence Y
description BINDING SITE FOR RESIDUE MG N 9281
source : OD3

77) chain N
residue 131
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9282
source : OD4

78) chain N
residue 132
type
sequence Y
description BINDING SITE FOR RESIDUE MG N 9282
source : OD4

79) chain N
residue 155
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9282
source : OD4

80) chain N
residue 684
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9288
source : OD6

81) chain N
residue 686
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9288
source : OD6

82) chain N
residue 1165
type
sequence Y
description BINDING SITE FOR RESIDUE MG N 9289
source : OD7

83) chain N
residue 1202
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9289
source : OD7

84) chain N
residue 799
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9291
source : OD8

85) chain N
residue 952
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9292
source : OD9

86) chain N
residue 2
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9295
source : PD2

87) chain N
residue 530
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9301
source : PD3

88) chain N
residue 531
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9301
source : PD3

89) chain N
residue 1162
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9305
source : PD6

90) chain N
residue 1387
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9307
source : PD7

91) chain N
residue 1391
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9307
source : PD7

92) chain N
residue 1393
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9307
source : PD7

93) chain N
residue 97
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9308
source : PD8

94) chain N
residue 571
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9308
source : PD8

95) chain N
residue 125
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9310
source : PD9

96) chain N
residue 587
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9310
source : PD9

97) chain N
residue 451
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9313
source : QD1

98) chain N
residue 453
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9313
source : QD1

99) chain N
residue 1031
type
sequence N
description BINDING SITE FOR RESIDUE MG N 9314
source : QD2

100) chain N
residue 1034
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9314
source : QD2

101) chain N
residue 1339
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9315
source : QD3

102) chain N
residue 504
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9319
source : QD4

103) chain N
residue 441
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9320
source : QD5

104) chain N
residue 1013
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9324
source : QD6

105) chain N
residue 144
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9327
source : QD7

106) chain N
residue 145
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9327
source : QD7

107) chain N
residue 1195
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9335
source : QD8

108) chain N
residue 668
type
sequence P
description BINDING SITE FOR RESIDUE MG N 9338
source : QD9

109) chain N
residue 805
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9339
source : RD1

110) chain N
residue 35
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9342
source : RD2

111) chain N
residue 75
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9343
source : RD3

112) chain N
residue 405
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9349
source : RD4

113) chain N
residue 408
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9349
source : RD4

114) chain N
residue 409
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9349
source : RD4

115) chain N
residue 504
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9352
source : RD5

116) chain N
residue 505
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9352
source : RD5

117) chain N
residue 531
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9354
source : RD6

118) chain N
residue 532
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9354
source : RD6

119) chain N
residue 1271
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9357
source : RD7

120) chain N
residue 71
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9360
source : RD8

121) chain N
residue 1242
type
sequence H
description BINDING SITE FOR RESIDUE MG N 9365
source : RD9

122) chain N
residue 1266
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9365
source : RD9

123) chain N
residue 823
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9368
source : SD1

124) chain N
residue 469
type
sequence D
description BINDING SITE FOR RESIDUE MG N 9371
source : SD2

125) chain N
residue 853
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9381
source : SD4

126) chain N
residue 40
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9387
source : SD6

127) chain N
residue 1307
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9475
source : SD8

128) chain N
residue 1308
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9475
source : SD8

129) chain N
residue 663
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9482
source : TD1

130) chain N
residue 664
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9482
source : TD1

131) chain N
residue 857
type
sequence I
description BINDING SITE FOR RESIDUE MG N 9486
source : TD2

132) chain N
residue 54
type
sequence K
description BINDING SITE FOR RESIDUE MG N 9501
source : TD4

133) chain N
residue 1069
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9504
source : TD5

134) chain N
residue 72
type
sequence V
description BINDING SITE FOR RESIDUE MG N 9506
source : TD6

135) chain N
residue 722
type
sequence E
description BINDING SITE FOR RESIDUE MG N 9508
source : TD7

136) chain N
residue 723
type
sequence G
description BINDING SITE FOR RESIDUE MG N 9508
source : TD7

137) chain N
residue 708
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9526
source : TD9

138) chain N
residue 1088
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9526
source : TD9

139) chain N
residue 1091
type
sequence S
description BINDING SITE FOR RESIDUE MG N 9526
source : TD9

140) chain N
residue 540
type
sequence L
description BINDING SITE FOR RESIDUE MG N 9531
source : UD2

141) chain N
residue 832
type
sequence R
description BINDING SITE FOR RESIDUE MG N 9539
source : UD5

142) chain N
residue 1004
type
sequence T
description BINDING SITE FOR RESIDUE MG N 9550
source : UD6

143) chain N
residue 1033
type
sequence Q
description BINDING SITE FOR RESIDUE MG N 9550
source : UD6

144) chain N
residue 925
type
sequence E
description BINDING SITE FOR RESIDUE MG O 9337
source : VD3

145) chain N
residue 613
type
sequence R
description BINDING SITE FOR RESIDUE MG P 9239
source : VD7

146) chain N
residue 58
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

147) chain N
residue 60
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

148) chain N
residue 73
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

149) chain N
residue 76
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

150) chain N
residue 739
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

151) chain N
residue 741
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

152) chain N
residue 743
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

153) chain N
residue 1112
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

154) chain N
residue 1194
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

155) chain N
residue 1201
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

156) chain N
residue 1204
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1


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