eF-site ID 2a68-M PDB Code 2a68 Chain M click to enlarge Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence M:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR Description Functional site 1) chain M residue 750 type sequence K description BINDING SITE FOR RESIDUE MG K 9495 source : CD9 2) chain M residue 134 type sequence R description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 3) chain M residue 390 type sequence Q description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 4) chain M residue 391 type sequence L description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 5) chain M residue 392 type sequence S description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 6) chain M residue 393 type sequence Q description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 7) chain M residue 394 type sequence F description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 8) chain M residue 395 type sequence K description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 9) chain M residue 396 type sequence D description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 10) chain M residue 406 type sequence H description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 11) chain M residue 409 type sequence R description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 12) chain M residue 411 type sequence S description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 13) chain M residue 413 type sequence L description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 14) chain M residue 444 type sequence P description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 15) chain M residue 452 type sequence I description BINDING SITE FOR RESIDUE RBT M 8002 source : ED9 16) chain M residue 740 type sequence E description BINDING SITE FOR RESIDUE MG M 9210 source : FD1 17) chain M residue 793 type sequence P description BINDING SITE FOR RESIDUE MG M 9211 source : FD2 18) chain M residue 794 type sequence P description BINDING SITE FOR RESIDUE MG M 9211 source : FD2 19) chain M residue 1004 type sequence K description BINDING SITE FOR RESIDUE MG M 9211 source : FD2 20) chain M residue 935 type sequence G description BINDING SITE FOR RESIDUE MG M 9216 source : FD3 21) chain M residue 936 type sequence V description BINDING SITE FOR RESIDUE MG M 9216 source : FD3 22) chain M residue 213 type sequence A description BINDING SITE FOR RESIDUE MG M 9219 source : FD4 23) chain M residue 214 type sequence Y description BINDING SITE FOR RESIDUE MG M 9219 source : FD4 24) chain M residue 215 type sequence G description BINDING SITE FOR RESIDUE MG M 9219 source : FD4 25) chain M residue 216 type sequence E description BINDING SITE FOR RESIDUE MG M 9219 source : FD4 26) chain M residue 743 type sequence V description BINDING SITE FOR RESIDUE MG M 9220 source : FD5 27) chain M residue 744 type sequence R description BINDING SITE FOR RESIDUE MG M 9220 source : FD5 28) chain M residue 745 type sequence I description BINDING SITE FOR RESIDUE MG M 9220 source : FD5 29) chain M residue 472 type sequence R description BINDING SITE FOR RESIDUE MG M 9222 source : FD6 30) chain M residue 499 type sequence A description BINDING SITE FOR RESIDUE MG M 9222 source : FD6 31) chain M residue 533 type sequence D description BINDING SITE FOR RESIDUE MG M 9222 source : FD6 32) chain M residue 249 type sequence K description BINDING SITE FOR RESIDUE MG M 9223 source : FD7 33) chain M residue 17 type sequence P description BINDING SITE FOR RESIDUE MG M 9224 source : FD8 34) chain M residue 20 type sequence E description BINDING SITE FOR RESIDUE MG M 9224 source : FD8 35) chain M residue 24 type sequence E description BINDING SITE FOR RESIDUE MG M 9224 source : FD8 36) chain M residue 4 type sequence K description BINDING SITE FOR RESIDUE MG M 9227 source : FD9 37) chain M residue 630 type sequence R description BINDING SITE FOR RESIDUE MG M 9229 source : GD1 38) chain M residue 244 type sequence P description BINDING SITE FOR RESIDUE MG M 9233 source : GD2 39) chain M residue 460 type sequence R description BINDING SITE FOR RESIDUE MG M 9241 source : GD3 40) chain M residue 56 type sequence E description BINDING SITE FOR RESIDUE MG M 9243 source : GD4 41) chain M residue 803 type sequence T description BINDING SITE FOR RESIDUE MG M 9251 source : GD5 42) chain M residue 618 type sequence G description BINDING SITE FOR RESIDUE MG M 9252 source : GD6 43) chain M residue 895 type sequence Y description BINDING SITE FOR RESIDUE MG M 9254 source : GD7 44) chain M residue 77 type sequence P description BINDING SITE FOR RESIDUE MG M 9255 source : GD8 45) chain M residue 251 type sequence D description BINDING SITE FOR RESIDUE MG M 9259 source : GD9 46) chain M residue 171 type sequence W description BINDING SITE FOR RESIDUE MG M 9261 source : HD1 47) chain M residue 629 type sequence Y description BINDING SITE FOR RESIDUE MG M 9268 source : HD3 48) chain M residue 895 type sequence Y description BINDING SITE FOR RESIDUE MG M 9276 source : HD4 49) chain M residue 41 type sequence N description BINDING SITE FOR RESIDUE MG M 9283 source : HD5 50) chain M residue 46 type sequence A description BINDING SITE FOR RESIDUE MG M 9283 source : HD5 51) chain M residue 383 type sequence R description BINDING SITE FOR RESIDUE MG M 9285 source : HD6 52) chain M residue 912 type sequence P description BINDING SITE FOR RESIDUE MG M 9290 source : HD7 53) chain M residue 1006 type sequence H description BINDING SITE FOR RESIDUE MG M 9293 source : HD8 54) chain M residue 1027 type sequence F description BINDING SITE FOR RESIDUE MG M 9293 source : HD8 55) chain M residue 1028 type sequence G description BINDING SITE FOR RESIDUE MG M 9293 source : HD8 56) chain M residue 1 type sequence M description BINDING SITE FOR RESIDUE MG M 9298 source : HD9 57) chain M residue 464 type sequence L description BINDING SITE FOR RESIDUE MG M 9312 source : ID2 58) chain M residue 1090 type sequence K description BINDING SITE FOR RESIDUE MG M 9323 source : ID4 59) chain M residue 1116 type sequence A description BINDING SITE FOR RESIDUE MG M 9323 source : ID4 60) chain M residue 104 type sequence D description BINDING SITE FOR RESIDUE MG M 9328 source : ID5 61) chain M residue 105 type sequence T description BINDING SITE FOR RESIDUE MG M 9328 source : ID5 62) chain M residue 82 type sequence E description BINDING SITE FOR RESIDUE MG M 9331 source : ID6 63) chain M residue 598 type sequence E description BINDING SITE FOR RESIDUE MG M 9336 source : ID8 64) chain M residue 481 type sequence D description BINDING SITE FOR RESIDUE MG M 9350 source : JD1 65) chain M residue 506 type sequence N description BINDING SITE FOR RESIDUE MG M 9350 source : JD1 66) chain M residue 1100 type sequence Q description BINDING SITE FOR RESIDUE MG M 9364 source : JD2 67) chain M residue 1111 type sequence I description BINDING SITE FOR RESIDUE MG M 9372 source : JD4 68) chain M residue 716 type sequence K description BINDING SITE FOR RESIDUE MG M 9373 source : JD5 69) chain M residue 209 type sequence R description BINDING SITE FOR RESIDUE MG M 9473 source : KD3 70) chain M residue 210 type sequence E description BINDING SITE FOR RESIDUE MG M 9473 source : KD3 71) chain M residue 27 type sequence R description BINDING SITE FOR RESIDUE MG M 9478 source : KD4 72) chain M residue 30 type sequence L description BINDING SITE FOR RESIDUE MG M 9478 source : KD4 73) chain M residue 31 type sequence Q description BINDING SITE FOR RESIDUE MG M 9478 source : KD4 74) chain M residue 33 type sequence D description BINDING SITE FOR RESIDUE MG M 9478 source : KD4 75) chain M residue 598 type sequence E description BINDING SITE FOR RESIDUE MG M 9481 source : KD5 76) chain M residue 567 type sequence Q description BINDING SITE FOR RESIDUE MG M 9485 source : KD6 77) chain M residue 838 type sequence K description BINDING SITE FOR RESIDUE MG M 9485 source : KD6 78) chain M residue 998 type sequence Y description BINDING SITE FOR RESIDUE MG M 9485 source : KD6 79) chain M residue 951 type sequence G description BINDING SITE FOR RESIDUE MG M 9488 source : KD7 80) chain M residue 780 type sequence E description BINDING SITE FOR RESIDUE MG M 9497 source : KD8 81) chain M residue 939 type sequence R description BINDING SITE FOR RESIDUE MG M 9500 source : KD9

Display surface Download Links