eF-site ID 2a68-L PDB Code 2a68 Chain L click to enlarge Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence L:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ Description Functional site 1) chain L residue 153 type sequence A description BINDING SITE FOR RESIDUE MG D 9042 source : OC3 2) chain L residue 154 type sequence E description BINDING SITE FOR RESIDUE MG D 9042 source : OC3 3) chain L residue 157 type sequence G description BINDING SITE FOR RESIDUE MG D 9042 source : OC3 4) chain L residue 13 type sequence V description BINDING SITE FOR RESIDUE MG K 9279 source : CD1 5) chain L residue 229 type sequence Q description BINDING SITE FOR RESIDUE MG L 9213 source : DD1 6) chain L residue 14 type sequence R description BINDING SITE FOR RESIDUE MG L 9236 source : DD2 7) chain L residue 15 type sequence T description BINDING SITE FOR RESIDUE MG L 9236 source : DD2 8) chain L residue 141 type sequence E description BINDING SITE FOR RESIDUE MG L 9258 source : DD4 9) chain L residue 160 type sequence D description BINDING SITE FOR RESIDUE MG L 9258 source : DD4 10) chain L residue 120 type sequence V description BINDING SITE FOR RESIDUE MG L 9260 source : DD5 11) chain L residue 121 type sequence E description BINDING SITE FOR RESIDUE MG L 9260 source : DD5 12) chain L residue 187 type sequence G description BINDING SITE FOR RESIDUE MG L 9272 source : DD7 13) chain L residue 188 type sequence Q description BINDING SITE FOR RESIDUE MG L 9272 source : DD7 14) chain L residue 101 type sequence L description BINDING SITE FOR RESIDUE MG L 9278 source : DD8 15) chain L residue 102 type sequence K description BINDING SITE FOR RESIDUE MG L 9278 source : DD8 16) chain L residue 227 type sequence N description BINDING SITE FOR RESIDUE MG L 9299 source : DD9 17) chain L residue 90 type sequence L description BINDING SITE FOR RESIDUE MG L 9300 source : ED1 18) chain L residue 1 type sequence M description BINDING SITE FOR RESIDUE MG L 9532 source : ED8 19) chain L residue 185 type sequence R description BINDING SITE FOR RESIDUE MG N 9509 source : TD8

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