eF-site ID 2a68-K PDB Code 2a68 Chain K click to enlarge Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence K:  MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPL RRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIIL NLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKD RINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW TDGSVTPLEALNQAVEILREHLTYFSNPQ Description Functional site 1) chain K residue 120 type sequence V description BINDING SITE FOR RESIDUE MG K 9212 source : BD4 2) chain K residue 122 type sequence I description BINDING SITE FOR RESIDUE MG K 9212 source : BD4 3) chain K residue 83 type sequence K description BINDING SITE FOR RESIDUE MG K 9214 source : BD5 4) chain K residue 85 type sequence L description BINDING SITE FOR RESIDUE MG K 9214 source : BD5 5) chain K residue 170 type sequence V description BINDING SITE FOR RESIDUE MG K 9214 source : BD5 6) chain K residue 88 type sequence R description BINDING SITE FOR RESIDUE MG K 9217 source : BD6 7) chain K residue 90 type sequence L description BINDING SITE FOR RESIDUE MG K 9217 source : BD6 8) chain K residue 119 type sequence D description BINDING SITE FOR RESIDUE MG K 9217 source : BD6 9) chain K residue 120 type sequence V description BINDING SITE FOR RESIDUE MG K 9217 source : BD6 10) chain K residue 121 type sequence E description BINDING SITE FOR RESIDUE MG K 9217 source : BD6 11) chain K residue 106 type sequence P description BINDING SITE FOR RESIDUE MG K 9257 source : BD7 12) chain K residue 137 type sequence R description BINDING SITE FOR RESIDUE MG K 9264 source : BD8 13) chain K residue 137 type sequence R description BINDING SITE FOR RESIDUE MG K 9265 source : BD9 14) chain K residue 229 type sequence Q description BINDING SITE FOR RESIDUE MG K 9279 source : CD1 15) chain K residue 14 type sequence R description BINDING SITE FOR RESIDUE MG K 9351 source : CD2 16) chain K residue 15 type sequence T description BINDING SITE FOR RESIDUE MG K 9351 source : CD2 17) chain K residue 16 type sequence Q description BINDING SITE FOR RESIDUE MG K 9351 source : CD2 18) chain K residue 227 type sequence N description BINDING SITE FOR RESIDUE MG K 9367 source : CD4 19) chain K residue 220 type sequence E description BINDING SITE FOR RESIDUE MG K 9370 source : CD5 20) chain K residue 221 type sequence H description BINDING SITE FOR RESIDUE MG K 9370 source : CD5 21) chain K residue 224 type sequence Y description BINDING SITE FOR RESIDUE MG K 9370 source : CD5 22) chain K residue 159 type sequence K description BINDING SITE FOR RESIDUE MG K 9492 source : CD8 23) chain K residue 154 type sequence E description BINDING SITE FOR RESIDUE MG K 9495 source : CD9 24) chain K residue 13 type sequence V description BINDING SITE FOR RESIDUE MG L 9213 source : DD1

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