eF-site ID 2a68-F PDB Code 2a68 Chain F click to enlarge Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence F:  KISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAI KKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDP KTVEEIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLR LVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRF KFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSR TARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQE PVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEE LEKALSKLSEREAMVLKLRKGLIDGEEVGAFFGVTRERIR QIENKALRKLKYHESRTRKLRDFLD Description Functional site 1) chain F residue 323 type sequence D description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 2) chain F residue 288 type sequence Y description BINDING SITE FOR RESIDUE MG C 9076 source : HC4 3) chain F residue 419 type sequence R description BINDING SITE FOR RESIDUE MG D 9118 source : SC3 4) chain F residue 87 type sequence E description BINDING SITE FOR RESIDUE MG D 9425 source : WC4 5) chain F residue 359 type sequence S description BINDING SITE FOR RESIDUE MG F 9010 source : YC8 6) chain F residue 360 type sequence K description BINDING SITE FOR RESIDUE MG F 9010 source : YC8 7) chain F residue 371 type sequence L description BINDING SITE FOR RESIDUE MG F 9030 source : YC9 8) chain F residue 372 type sequence R description BINDING SITE FOR RESIDUE MG F 9030 source : YC9 9) chain F residue 83 type sequence Q description BINDING SITE FOR RESIDUE MG F 9032 source : ZC1 10) chain F residue 87 type sequence E description BINDING SITE FOR RESIDUE MG F 9032 source : ZC1 11) chain F residue 403 type sequence K description BINDING SITE FOR RESIDUE MG F 9035 source : ZC2 12) chain F residue 407 type sequence K description BINDING SITE FOR RESIDUE MG F 9035 source : ZC2 13) chain F residue 111 type sequence E description BINDING SITE FOR RESIDUE MG F 9045 source : ZC3 14) chain F residue 115 type sequence K description BINDING SITE FOR RESIDUE MG F 9045 source : ZC3 15) chain F residue 173 type sequence Y description BINDING SITE FOR RESIDUE MG F 9045 source : ZC3 16) chain F residue 97 type sequence E description BINDING SITE FOR RESIDUE MG F 9053 source : ZC4 17) chain F residue 100 type sequence V description BINDING SITE FOR RESIDUE MG F 9053 source : ZC4 18) chain F residue 104 type sequence R description BINDING SITE FOR RESIDUE MG F 9053 source : ZC4 19) chain F residue 360 type sequence K description BINDING SITE FOR RESIDUE MG F 9054 source : ZC5 20) chain F residue 363 type sequence E description BINDING SITE FOR RESIDUE MG F 9072 source : ZC6 21) chain F residue 377 type sequence D description BINDING SITE FOR RESIDUE MG F 9089 source : ZC7 22) chain F residue 147 type sequence L description BINDING SITE FOR RESIDUE MG F 9133 source : ZC8 23) chain F residue 360 type sequence K description BINDING SITE FOR RESIDUE MG F 9135 source : ZC9 24) chain F residue 272 type sequence S description BINDING SITE FOR RESIDUE MG F 9153 source : AD1 25) chain F residue 308 type sequence L description BINDING SITE FOR RESIDUE MG F 9153 source : AD1 26) chain F residue 244 type sequence R description BINDING SITE FOR RESIDUE MG F 9164 source : AD2 27) chain F residue 352 type sequence E description BINDING SITE FOR RESIDUE MG F 9167 source : AD3 28) chain F residue 340 type sequence S description BINDING SITE FOR RESIDUE MG F 9197 source : AD4 29) chain F residue 342 type sequence V description BINDING SITE FOR RESIDUE MG F 9197 source : AD4 30) chain F residue 335 type sequence D description BINDING SITE FOR RESIDUE MG F 9407 source : AD6 31) chain F residue 338 type sequence L description BINDING SITE FOR RESIDUE MG F 9407 source : AD6 32) chain F residue 339 type sequence P description BINDING SITE FOR RESIDUE MG F 9407 source : AD6 33) chain F residue 340 type sequence S description BINDING SITE FOR RESIDUE MG F 9407 source : AD6 34) chain F residue 153 type sequence P description BINDING SITE FOR RESIDUE MG F 9410 source : AD7 35) chain F residue 366 type sequence A description BINDING SITE FOR RESIDUE MG F 9421 source : AD8 36) chain F residue 370 type sequence K description BINDING SITE FOR RESIDUE MG F 9421 source : AD8 37) chain F residue 322 type sequence G description BINDING SITE FOR RESIDUE MG F 9435 source : AD9 38) chain F residue 173 type sequence Y description BINDING SITE FOR RESIDUE MG F 9465 source : BD2 39) chain F residue 263 type sequence H description BINDING SITE FOR RESIDUE MG M 9380 source : JD6 40) chain F residue 187-194 type prosite sequence LIEANLRL description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL source prosite : PS00867

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