eF-site ID 2a68-C PDB Code 2a68 Chain C click to enlarge Title Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR Description Functional site 1) chain C residue 863 type sequence D description BINDING SITE FOR RESIDUE MG A 9178 source : BC8 2) chain C residue 698 type sequence D description BINDING SITE FOR RESIDUE MG A 9411 source : CC3 3) chain C residue 979 type sequence T description BINDING SITE FOR RESIDUE MG B 9137 source : DC6 4) chain C residue 981 type sequence E description BINDING SITE FOR RESIDUE MG B 9137 source : DC6 5) chain C residue 134 type sequence R description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 6) chain C residue 390 type sequence Q description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 7) chain C residue 392 type sequence S description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 8) chain C residue 393 type sequence Q description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 9) chain C residue 394 type sequence F description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 10) chain C residue 396 type sequence D description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 11) chain C residue 406 type sequence H description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 12) chain C residue 409 type sequence R description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 13) chain C residue 411 type sequence S description BINDING SITE FOR RESIDUE RBT C 8001 source : FC1 14) chain C residue 144 type sequence P description BINDING SITE FOR RESIDUE MG C 9004 source : FC2 15) chain C residue 165 type sequence L description BINDING SITE FOR RESIDUE MG C 9004 source : FC2 16) chain C residue 265 type sequence R description BINDING SITE FOR RESIDUE MG C 9004 source : FC2 17) chain C residue 267 type sequence Y description BINDING SITE FOR RESIDUE MG C 9004 source : FC2 18) chain C residue 491 type sequence E description BINDING SITE FOR RESIDUE MG C 9005 source : FC3 19) chain C residue 492 type sequence D description BINDING SITE FOR RESIDUE MG C 9005 source : FC3 20) chain C residue 518 type sequence K description BINDING SITE FOR RESIDUE MG C 9005 source : FC3 21) chain C residue 932 type sequence E description BINDING SITE FOR RESIDUE MG C 9007 source : FC4 22) chain C residue 1007 type sequence A description BINDING SITE FOR RESIDUE MG C 9011 source : FC5 23) chain C residue 1026 type sequence Q description BINDING SITE FOR RESIDUE MG C 9011 source : FC5 24) chain C residue 1027 type sequence F description BINDING SITE FOR RESIDUE MG C 9011 source : FC5 25) chain C residue 787 type sequence D description BINDING SITE FOR RESIDUE MG C 9014 source : FC6 26) chain C residue 1092 type sequence L description BINDING SITE FOR RESIDUE MG C 9020 source : FC7 27) chain C residue 1097 type sequence L description BINDING SITE FOR RESIDUE MG C 9020 source : FC7 28) chain C residue 1098 type sequence D description BINDING SITE FOR RESIDUE MG C 9020 source : FC7 29) chain C residue 1099 type sequence V description BINDING SITE FOR RESIDUE MG C 9020 source : FC7 30) chain C residue 219 type sequence Q description BINDING SITE FOR RESIDUE MG C 9022 source : FC8 31) chain C residue 220 type sequence G description BINDING SITE FOR RESIDUE MG C 9022 source : FC8 32) chain C residue 223 type sequence D description BINDING SITE FOR RESIDUE MG C 9022 source : FC8 33) chain C residue 595 type sequence L description BINDING SITE FOR RESIDUE MG C 9023 source : FC9 34) chain C residue 596 type sequence Y description BINDING SITE FOR RESIDUE MG C 9023 source : FC9 35) chain C residue 405 type sequence R description BINDING SITE FOR RESIDUE MG C 9025 source : GC1 36) chain C residue 563 type sequence N description BINDING SITE FOR RESIDUE MG C 9025 source : GC1 37) chain C residue 1035 type sequence M description BINDING SITE FOR RESIDUE MG C 9027 source : GC2 38) chain C residue 11 type sequence E description BINDING SITE FOR RESIDUE MG C 9028 source : GC3 39) chain C residue 12 type sequence V description BINDING SITE FOR RESIDUE MG C 9028 source : GC3 40) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE MG C 9028 source : GC3 41) chain C residue 14 type sequence P description BINDING SITE FOR RESIDUE MG C 9028 source : GC3 42) chain C residue 274 type sequence R description BINDING SITE FOR RESIDUE MG C 9029 source : GC4 43) chain C residue 278 type sequence E description BINDING SITE FOR RESIDUE MG C 9029 source : GC4 44) chain C residue 1027 type sequence F description BINDING SITE FOR RESIDUE MG C 9031 source : GC5 45) chain C residue 154 type sequence R description BINDING SITE FOR RESIDUE MG C 9044 source : GC6 46) chain C residue 156 type sequence G description BINDING SITE FOR RESIDUE MG C 9044 source : GC6 47) chain C residue 157 type sequence R description BINDING SITE FOR RESIDUE MG C 9044 source : GC6 48) chain C residue 181 type sequence V description BINDING SITE FOR RESIDUE MG C 9046 source : GC7 49) chain C residue 182 type sequence V description BINDING SITE FOR RESIDUE MG C 9046 source : GC7 50) chain C residue 183 type sequence S description BINDING SITE FOR RESIDUE MG C 9046 source : GC7 51) chain C residue 708 type sequence Y description BINDING SITE FOR RESIDUE MG C 9047 source : GC8 52) chain C residue 793 type sequence P description BINDING SITE FOR RESIDUE MG C 9047 source : GC8 53) chain C residue 794 type sequence P description BINDING SITE FOR RESIDUE MG C 9047 source : GC8 54) chain C residue 795 type sequence G description BINDING SITE FOR RESIDUE MG C 9047 source : GC8 55) chain C residue 796 type sequence E description BINDING SITE FOR RESIDUE MG C 9047 source : GC8 56) chain C residue 29 type sequence A description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 57) chain C residue 30 type sequence L description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 58) chain C residue 31 type sequence Q description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 59) chain C residue 44 type sequence I description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 60) chain C residue 45 type sequence Q description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 61) chain C residue 71 type sequence Y description BINDING SITE FOR RESIDUE MG C 9056 source : GC9 62) chain C residue 166 type sequence P description BINDING SITE FOR RESIDUE MG C 9068 source : HC2 63) chain C residue 168 type sequence R description BINDING SITE FOR RESIDUE MG C 9068 source : HC2 64) chain C residue 820 type sequence R description BINDING SITE FOR RESIDUE MG C 9074 source : HC3 65) chain C residue 815 type sequence L description BINDING SITE FOR RESIDUE MG C 9076 source : HC4 66) chain C residue 816 type sequence K description BINDING SITE FOR RESIDUE MG C 9076 source : HC4 67) chain C residue 817 type sequence P description BINDING SITE FOR RESIDUE MG C 9076 source : HC4 68) chain C residue 957 type sequence K description BINDING SITE FOR RESIDUE MG C 9081 source : HC5 69) chain C residue 958 type sequence T description BINDING SITE FOR RESIDUE MG C 9081 source : HC5 70) chain C residue 961 type sequence E description BINDING SITE FOR RESIDUE MG C 9081 source : HC5 71) chain C residue 231 type sequence P description BINDING SITE FOR RESIDUE MG C 9106 source : HC8 72) chain C residue 906 type sequence F description BINDING SITE FOR RESIDUE MG C 9121 source : IC1 73) chain C residue 910 type sequence K description BINDING SITE FOR RESIDUE MG C 9121 source : IC1 74) chain C residue 713 type sequence R description BINDING SITE FOR RESIDUE MG C 9124 source : IC2 75) chain C residue 714 type sequence D description BINDING SITE FOR RESIDUE MG C 9124 source : IC2 76) chain C residue 318 type sequence P description BINDING SITE FOR RESIDUE MG C 9127 source : IC3 77) chain C residue 857 type sequence D description BINDING SITE FOR RESIDUE MG C 9130 source : IC4 78) chain C residue 5 type sequence R description BINDING SITE FOR RESIDUE MG C 9144 source : IC5 79) chain C residue 11 type sequence E description BINDING SITE FOR RESIDUE MG C 9144 source : IC5 80) chain C residue 581 type sequence T description BINDING SITE FOR RESIDUE MG C 9144 source : IC5 81) chain C residue 904 type sequence P description BINDING SITE FOR RESIDUE MG C 9144 source : IC5 82) chain C residue 266 type sequence R description BINDING SITE FOR RESIDUE MG C 9156 source : IC6 83) chain C residue 345 type sequence R description BINDING SITE FOR RESIDUE MG C 9156 source : IC6 84) chain C residue 297 type sequence E description BINDING SITE FOR RESIDUE MG C 9157 source : IC7 85) chain C residue 602 type sequence E description BINDING SITE FOR RESIDUE MG C 9160 source : IC8 86) chain C residue 1075 type sequence D description BINDING SITE FOR RESIDUE MG C 9161 source : IC9 87) chain C residue 1047 type sequence H description BINDING SITE FOR RESIDUE MG C 9170 source : JC1 88) chain C residue 829 type sequence Q description BINDING SITE FOR RESIDUE MG C 9171 source : JC2 89) chain C residue 830 type sequence K description BINDING SITE FOR RESIDUE MG C 9171 source : JC2 90) chain C residue 831 type sequence R description BINDING SITE FOR RESIDUE MG C 9171 source : JC2 91) chain C residue 832 type sequence K description BINDING SITE FOR RESIDUE MG C 9171 source : JC2 92) chain C residue 243 type sequence R description BINDING SITE FOR RESIDUE MG C 9177 source : JC3 93) chain C residue 244 type sequence P description BINDING SITE FOR RESIDUE MG C 9177 source : JC3 94) chain C residue 939 type sequence R description BINDING SITE FOR RESIDUE MG C 9190 source : JC5 95) chain C residue 933 type sequence G description BINDING SITE FOR RESIDUE MG C 9198 source : JC7 96) chain C residue 511 type sequence E description BINDING SITE FOR RESIDUE MG C 9201 source : JC8 97) chain C residue 422 type sequence R description BINDING SITE FOR RESIDUE MG C 9204 source : JC9 98) chain C residue 673 type sequence L description BINDING SITE FOR RESIDUE MG C 9398 source : KC1 99) chain C residue 868 type sequence D description BINDING SITE FOR RESIDUE MG C 9398 source : KC1 100) chain C residue 895 type sequence Y description BINDING SITE FOR RESIDUE MG C 9398 source : KC1 101) chain C residue 1072 type sequence K description BINDING SITE FOR RESIDUE MG C 9399 source : KC2 102) chain C residue 1073 type sequence G description BINDING SITE FOR RESIDUE MG C 9399 source : KC2 103) chain C residue 728 type sequence H description BINDING SITE FOR RESIDUE MG C 9414 source : KC4 104) chain C residue 762 type sequence K description BINDING SITE FOR RESIDUE MG C 9414 source : KC4 105) chain C residue 308 type sequence R description BINDING SITE FOR RESIDUE MG C 9415 source : KC5 106) chain C residue 555 type sequence A description BINDING SITE FOR RESIDUE MG C 9420 source : KC6 107) chain C residue 556 type sequence N description BINDING SITE FOR RESIDUE MG C 9420 source : KC6 108) chain C residue 320 type sequence H description BINDING SITE FOR RESIDUE MG C 9426 source : KC7 109) chain C residue 322 type sequence V description BINDING SITE FOR RESIDUE MG C 9426 source : KC7 110) chain C residue 230 type sequence R description BINDING SITE FOR RESIDUE MG C 9428 source : KC8 111) chain C residue 5 type sequence R description BINDING SITE FOR RESIDUE MG C 9431 source : KC9 112) chain C residue 7 type sequence G description BINDING SITE FOR RESIDUE MG C 9431 source : KC9 113) chain C residue 11 type sequence E description BINDING SITE FOR RESIDUE MG C 9431 source : KC9 114) chain C residue 904 type sequence P description BINDING SITE FOR RESIDUE MG C 9431 source : KC9 115) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE MG C 9456 source : LC3 116) chain C residue 121 type sequence M description BINDING SITE FOR RESIDUE MG C 9456 source : LC3 117) chain C residue 1061 type sequence E description BINDING SITE FOR RESIDUE MG C 9515 source : LC7 118) chain C residue 1062 type sequence G description BINDING SITE FOR RESIDUE MG C 9515 source : LC7 119) chain C residue 1065 type sequence A description BINDING SITE FOR RESIDUE MG C 9515 source : LC7 120) chain C residue 109 type sequence K description BINDING SITE FOR RESIDUE MG C 9546 source : LC9 121) chain C residue 949 type sequence K description BINDING SITE FOR RESIDUE MG D 9013 source : NC1 122) chain C residue 1109 type sequence V description BINDING SITE FOR RESIDUE MG D 9015 source : NC2 123) chain C residue 1013 type sequence Y description BINDING SITE FOR RESIDUE MG F 9407 source : AD6 124) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

Display surface Download Links