eF-site ID 2a4q-ABCD PDB Code 2a4q Chain A, B, C, D click to enlarge Title HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound. Classification VIRAL PROTEIN Compound NS3 protease/helicase' Source null (O39914_9HEPC) Sequence A:  APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAT QTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQ DLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG DSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCT RGVAKAVDFIPVENLETTMRS B:  KGSVVIVGRIVLSGKPAIIPKK C:  VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPK GPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGLFRAAVCTRGVAKAVDFIPVENLETTM D:  GSVVIVGRIVLSGKPA Description Functional site 1) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 2) chain A residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 3) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 4) chain C residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 5) chain C residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 6) chain C residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 7) chain A residue 13 type sequence L description BINDING SITE FOR RESIDUE BME A 201 source : AC3 8) chain A residue 16 type sequence C description BINDING SITE FOR RESIDUE BME A 201 source : AC3 9) chain A residue 17 type sequence I description BINDING SITE FOR RESIDUE BME A 201 source : AC3 10) chain A residue 38 type sequence T description BINDING SITE FOR RESIDUE BME A 201 source : AC3 11) chain A residue 41 type sequence Q description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 12) chain A residue 42 type sequence T description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 13) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 14) chain A residue 135 type sequence L description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 15) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 16) chain A residue 137 type sequence G description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 17) chain A residue 138 type sequence S description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 18) chain A residue 139 type sequence S description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 19) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 20) chain A residue 156 type sequence A description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 21) chain A residue 157 type sequence A description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 22) chain A residue 159 type sequence C description BINDING SITE FOR RESIDUE FNH A 401 source : AC4 23) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE FNH A 401 source : AC4

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