eF-site ID 2a4l-A PDB Code 2a4l Chain A click to enlarge Title Human cyclin-dependent kinase 2 in complex with roscovitine Classification TRANSFERASE Compound Homo sapiens cyclin-dependent kinase 2 Source (AAP36159) Sequence A:  MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIAIREI SLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMD ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQN LLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP VPHLRL Description Functional site 1) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 2) chain A residue 18 type sequence V description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 3) chain A residue 31 type sequence A description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 4) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 5) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 6) chain A residue 82 type sequence F description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 7) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 8) chain A residue 84 type sequence H description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 9) chain A residue 89 type sequence K description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 10) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 11) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 12) chain A residue 144 type sequence A description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 13) chain A residue 145 type sequence D description BINDING SITE FOR RESIDUE RRC A 300 source : AC1 14) chain A residue 10-33 type prosite sequence IGEGTYGVVYKARNKLTGEVVALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK source prosite : PS00107 15) chain A residue 123-135 type prosite sequence VLHRDLKPQNLLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI source prosite : PS00108

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