eF-site ID 2a4g-ABCD PDB Code 2a4g Chain A, B, C, D click to enlarge Title Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound Classification VIRAL PROTEIN Compound NS3 protease/helicase Source (AAT94284) Sequence A:  APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAT QTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQ DLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG DSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCT RGVAKAVDFIPVENLETTMRS B:  KGSVVIVGRIVLSGKPAIIPKK C:  VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPK GPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGLFRAAVCTRGVAKAVDFIPVENLETTM D:  GSVVIVGRIVLSGKPA Description Functional site 1) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 2) chain A residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 3) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 301 source : AC1 4) chain C residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 5) chain C residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 6) chain C residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN C 302 source : AC2 7) chain A residue 41 type sequence Q description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 8) chain A residue 42 type sequence T description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 9) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 10) chain A residue 123 type sequence R description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 11) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 12) chain A residue 137 type sequence G description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 13) chain A residue 138 type sequence S description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 14) chain A residue 139 type sequence S description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 15) chain A residue 154 type sequence F description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 16) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 17) chain A residue 156 type sequence A description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 18) chain A residue 157 type sequence A description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 19) chain A residue 159 type sequence C description BINDING SITE FOR RESIDUE UNH A 401 source : AC3 20) chain A residue 57 type ACT_SITE sequence H description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 81 type ACT_SITE sequence D description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 139 type ACT_SITE sequence S description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 57 type ACT_SITE sequence H description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 81 type ACT_SITE sequence D description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 25) chain C residue 139 type ACT_SITE sequence S description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 145 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 27) chain C residue 149 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 97 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 99 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 145 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 149 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 32) chain C residue 97 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 33) chain C residue 99 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2

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