eF-site ID 2a41-B PDB Code 2a41 Chain B click to enlarge Title Ternary complex of the WH2 Domain of WIP with Actin-DNAse I Classification STRUCTURAL PROTEIN Compound Actin, alpha skeletal muscle Source ORGANISM_COMMON: rabbit; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus; Sequence B:  LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEV RDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERY LFLFRPNKVSVLDTYQYDDGCESCGNDSFSREPAVVKFSS HSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKWHL NDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSA DTTATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYG LSNEMALAISDHYPVEVTLT Description Functional site 1) chain B residue 134 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:2395459, ECO:0000269|PubMed:4976790 source Swiss-Prot : SWS_FT_FI2 2) chain B residue 67 type SITE sequence V description Involved in actin-binding => ECO:0000269|PubMed:2395459 source Swiss-Prot : SWS_FT_FI3 3) chain B residue 13 type SITE sequence E description Involved in actin-binding => ECO:0000269|PubMed:2395459 source Swiss-Prot : SWS_FT_FI3 4) chain B residue 65 type SITE sequence Y description Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme source Swiss-Prot : SWS_FT_FI4 5) chain B residue 18 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1748997, ECO:0000269|PubMed:3560229 source Swiss-Prot : SWS_FT_FI5 6) chain B residue 167-174 type prosite sequence GDFNADCS description DNASE_I_2 Deoxyribonuclease I signature 2. GDFNAdCS source prosite : PS00918 7) chain B residue 130-150 type prosite sequence IVALHSAPSDAVAEINSLYDV description DNASE_I_1 Deoxyribonuclease I signature 1. IVALHSAPsdavaEINsLyDV source prosite : PS00919 8) chain B residue 39 type catalytic sequence E description 41 source MCSA : MCSA1 9) chain B residue 76 type catalytic sequence Y description 41 source MCSA : MCSA1 10) chain B residue 78 type catalytic sequence E description 41 source MCSA : MCSA1 11) chain B residue 134 type catalytic sequence H description 41 source MCSA : MCSA1 12) chain B residue 168 type catalytic sequence D description 41 source MCSA : MCSA1 13) chain B residue 212 type catalytic sequence D description 41 source MCSA : MCSA1 14) chain B residue 252 type catalytic sequence H description 41 source MCSA : MCSA1

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